(E)-1-{4-[2-({2-[2-(2-aminooxy-ethoxy)-ethoxy]-ethyl}-methyl-amino)-ethoxy]-phenyl}-1-(4-hydroxyphenyl)-2-phenyl-butene | 671791-68-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1-{4-[2-({2-[2-(2-aminooxy-ethoxy)-ethoxy]-ethyl}-methyl-amino)-ethoxy]-phenyl}-1-(4-hydroxyphenyl)-2-phenyl-butene
• 英文别名: 4-[(E)-1-[4-[2-[2-[2-(2-aminooxyethoxy)ethoxy]ethyl-methylamino]ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
• CAS: 671791-68-7
• 化学式: C₃₁H₄₀N₂O₅
• 分子量: 520.669
• InChiKey: ZXRYUZAQEWNAJT-NVQSTNCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  38
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  86.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• [EN] TARGETED DRUG-FORMALDEHYDE CONJUGATES AND METHODS OF MAKING AND USING THE SAME<br/>[FR] CONJUGUES CIBLES MEDICAMENT-FORMALDEHYDE ET PROCEDES DE FABRICATION ASSOCIES
  申请人：UNIV COLORADO

  公开号：WO2005034856A2

  公开（公告）日：2005-04-21

  The invention provides a prodrug platform technology for improving the therapeutic value of a variety of parent drug compounds by altering and improving drug characteristics such as aqueous solubility, hydrolytic stability, therapeutic index, toxicity profile, pharmacokinetics and selectivity while allowing the potential for synthetic elaboration. The prodrug platform is particularly well suited for targeting therapeutic drugs, including anti-tumor drugs and antibiotics, to specific receptors on target cells (e.g., cancer cells and bacteria). The platform is a technology for providing an improved, preactivated form of a therapeutic drug, and for optionally targeting such drug to target cells or biological molecules. The invention is broadly applicable to many different therapeutic drugs, as well as to a variety of diseases and conditions, including a variety of forms of cancer and bacterial infections.