Tert-butyl 4-(3,5-dimethylpiperidine-1-carbonyl)piperidine-1-carboxylate | 287954-32-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: Tert-butyl 4-(3,5-dimethylpiperidine-1-carbonyl)piperidine-1-carboxylate
• CAS: 287954-32-9
• 化学式: C₁₈H₃₂N₂O₃
• 分子量: 324.464
• InChiKey: YIVGJTHDDFVRAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Tert-butyl 4-(3,5-dimethylpiperidine-1-carbonyl)piperidine-1-carboxylate 在 盐酸 作用下， 生成 C₁₃H₂₄N₂O
  参考文献：
  名称：

  MMP-13 selective isonipecotamide α-sulfone hydroxamates

  摘要：

  A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.111
• 作为产物：
  描述：

  3,5-二甲基哌啶 、 1-Boc-4-哌啶甲酸 在 2-氯-4,6-二甲氧基-1,3,5-三嗪 作用下， 生成 Tert-butyl 4-(3,5-dimethylpiperidine-1-carbonyl)piperidine-1-carboxylate
  参考文献：
  名称：

  MMP-13 selective isonipecotamide α-sulfone hydroxamates

  摘要：

  A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.111

文献信息

• MMP-13 selective isonipecotamide α-sulfone hydroxamates
  作者：Stephen A. Kolodziej、Susan L. Hockerman、Gary A. DeCrescenzo、Joseph J. McDonald、Debbie A. Mischke、Grace E. Munie、Theresa R. Fletcher、Nathan Stehle、Craig Swearingen、Daniel P. Becker

  DOI：10.1016/j.bmcl.2010.04.111

  日期：2010.6

  A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13. (C) 2010 Elsevier Ltd. All rights reserved.