1,2,3,4-Tetrahydro-6-methoxy-2-[[(4-methoxy phenyl)amino]carbonyl]-5 (phenylmethoxy)-3-isoquinolinecarboxylic acid | 152362-56-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: 1,2,3,4-Tetrahydro-6-methoxy-2-[[(4-methoxy phenyl)amino]carbonyl]-5 (phenylmethoxy)-3-isoquinolinecarboxylic acid
• 英文别名: 5-Benzyloxy-6-methoxy-2-(4-methoxy-phenylcarbamoyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid；6-methoxy-2-[(4-methoxyphenyl)carbamoyl]-5-phenylmethoxy-3,4-dihydro-1H-isoquinoline-3-carboxylic acid
• CAS: 152362-56-6
• 化学式: C₂₆H₂₆N₂O₆
• 分子量: 462.502
• InChiKey: PSJJMQJLCQVKBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  97.3
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SUBSTITUTED 1,2,3,4-TETRAHYDROISOQUINOLINES WITH ANGIOTENSIN II RECEPTOR ANTAGONIST PROPERTIES
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0641326A1

  公开（公告）日：1995-03-08
• Method of Treatment or Prophylaxis of Inflammatory Pain
  申请人：Spinifex Pharmaceuticals Pty Ltd

  公开号：US20140142116A1

  公开（公告）日：2014-05-22

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.
• METHOD OF TREATMENT OR PROPHYLAXIS INFTAMMATORY PAIN
  申请人：Novartis AG

  公开号：US20160052925A1

  公开（公告）日：2016-02-25

  A method of treatment, reversal and/or symptomatic relief of inflammatory pain, including hyperalgesia, thermal or mechanical allodynia, in vertebrate animals, particularly in human subjects, comprising administering angiotensin II receptor 2 (AT 2 receptor) antagonists is disclosed. The AT 2 receptor antagonist may be provided alone or in combination with other compounds such as those that are useful in the control of inflammatory pain.
• US5246943A
  申请人：——

  公开号：US5246943A

  公开（公告）日：1993-09-21
• US5350757A
  申请人：——

  公开号：US5350757A

  公开（公告）日：1994-09-27