1,2-bis-[4-(2-carboxy-ethyl)-phenoxy]-ethane | 95556-86-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 1,2-bis-[4-(2-carboxy-ethyl)-phenoxy]-ethane
• 英文别名: 1,2-Bis-[4-(2-carboxy-aethyl)-phenoxy]-aethan
• CAS: 95556-86-8
• 化学式: C₂₀H₂₂O₆
• 分子量: 358.391
• InChiKey: MOZGGNNQRGBIIP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.18
• 重原子数：
  26.0
• 可旋转键数：
  11.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  93.06
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  1,2-bis-[4-(2-methoxycarbonyl-ethyl)-phenoxy]-ethane 在 sodium hydroxide 作用下， 生成 1,2-bis-[4-(2-carboxy-ethyl)-phenoxy]-ethane
  参考文献：
  名称：

  The localization of type 2 diabetes susceptibility gene loci in northern Chinese Han families

  摘要：

  We conducted a genome-wide scan, in which 358 well distributed fluorescent dye-labeled microsatellite marker sets were applied in 32 Chinese Han type 2 diabetes families from Northern China to search for the susceptibility gene loci. The data collected from screening all the chromosomes of genome were genotyped by using genescan and genotyping software, then, parametric and non-parametric multipoint test, and affected sib-pair analysis as well, were used to analyze the data. We identified some susceptibility gene loci residing in chromosomes 1,12,18,20, respectively, or precisely, located around D1S214, D1S207, D1S218, D1S235, D12S336, D18S61 and D20S118. The comparison of this result with those from other regions and races reflected the complexity and heterogeneity of type 2 diabetes.

  DOI：

  10.1007/bf02886269