N-(4-chlorophenyl)-2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazine-1-carbothioamide | 79560-86-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: N-(4-chlorophenyl)-2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazine-1-carbothioamide
• CAS: 79560-86-4
• 化学式: C₂₀H₂₀ClN₅O₂S
• 分子量: 429.93
• InChiKey: YHYKDYWPNDZEOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.67
• 重原子数：
  29.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  69.2
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  靛红 在 aluminum oxide 作用下， 以 乙醇 、 水 为溶剂， 反应 0.19h， 生成 N-(4-chlorophenyl)-2-(1-(morpholinomethyl)-2-oxoindolin-3-ylidene)hydrazine-1-carbothioamide
  参考文献：
  名称：

  AQUA MEDIATED ONE POT FACILE SYNTHESIS OF NOVEL THIOXO-1,2,4-TRIAZIN-5(2H)-ONE AND [1,2,4] TRIAZINO[5,6-A]INDOLE DERIVATIVES AND THEIR BIOLOGICAL ACTIVITIES

  摘要：

  Rapid and highly efficient one pot green chemical synthesis of substituted 6-(2-aminophenyl)-4-(4-substitutedphenyl)-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2H)-one and 8-substituted-3,5-dihydro-2H-[1,2,4]triazino[5,6-b]indole is carried out in aqueous medium under microwave irradiation. Improved synthesis of potent bioactive Schiff and N-Mannich bases of hexahydro-1H-indole-2,3-dione is also reported. The title compounds are easily accessible by various approaches; even waste free approaches have been developed. The operational simplicity, environmentally benign conditions and high yield achieved in a very short reaction time are major benefits that meet the requirements of green production, including saving energy and high efficiency. The results obtained under microwaves are compared with that of conventional heating. Structural assignments are based on spectroscopic data. Compounds have also been screened for antibacterial and antifungal activities.

  DOI：

  10.4067/s0717-97072012000400004

文献信息

• Potential Biologically Active Agents, XXXII. Synthesis and Antiviral Activity of Some 3-(Arylthiosemicarbazono)-2-indolinones
  作者：Rajendra S. Varma、Pradeep K. Garg、Hirday N. Verma、Lalji P. Awasthi

  DOI：10.1002/ardp.19813141105

  日期：——

  A series of 3‐(arylthiosemicarbazono)‐2‐indolinones 1, 1‐methyl‐3‐(arylthiosemicarbazono)‐2‐indolinones 2 and 1‐(aminomethyl)‐3‐(arylthiosemicarbazono)‐2‐indolinones 3 have been synthesised. All compounds were screened for their antiviral activity against Sunnhemp rosette virus (SRV) in vitro as well as in vivo. Twelve compounds show significant antiviral activity.

  已经合成了一系列 3- (芳基氨基硫代) -2- 吲哚酮 1, 1- 甲基 - 3- (芳基氨基硫代) -2- 吲哚啉酮 2 和 1- (氨基甲基) -3- (芳基氨基硫代) -2- 吲哚酮 3。筛选了所有化合物在体外和体内对 Sunnhemp 玫瑰花结病毒 (SRV) 的抗病毒活性。十二种化合物显示出显着的抗病毒活性。