(3S,5S,6R)-2,3,5,6-Tetrahydro-3--5,6-diphenyl-1,4-oxazin-2-one | 144744-32-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (3S,5S,6R)-2,3,5,6-Tetrahydro-3--5,6-diphenyl-1,4-oxazin-2-one
• 英文别名: (3S,5S,6R)-5,6-diphenyl-3-[4-(trifluoromethyl)phenyl]morpholin-2-one
• CAS: 144744-32-1
• 化学式: C₂₃H₁₈F₃NO₂
• 分子量: 397.397
• InChiKey: ASKMQLGJYHTMGY-PCCBWWKXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.38
• 重原子数：
  29.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.33
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  (1R,2S)-2-氨基-1,2-二苯基乙醇 、 alkaline earth salt of/the/ methylsulfuric acid 生成 (3R,5S,6R)-2,3,5,6-Tetrahydro-3--5,6-diphenyl-1,4-oxazin-2-one 、 (3S,5S,6R)-2,3,5,6-Tetrahydro-3--5,6-diphenyl-1,4-oxazin-2-one
  参考文献：
  名称：

  Synthesis of optically active arylglycines by photolysis of optically active (.beta.-hydroxyamino) carbene-chromium(0) complexes

  摘要：

  Photolysis of [(amino)(aryl)carbene]chromium complexes having the optically active amino alcohol (1R,2S-(-)- or (1S,2R)-(+)-2-amino-1,2-diphenylethanol as the amino group produced aryl-substituted oxazinones in good yield with reasonable diastereoselectivity. Facile separation of diastereoisomers followed by mild reductive cleavage produced several arylglycines, having either electron-donating or withdrawing groups on the aromatic ring, in good overall yield and with excellent enantiomeric excess.

  DOI：

  10.1021/jo00051a044