N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)acetamide | 1123234-41-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-(2-{1-[4-(2-naphthyl)pyrimidin-2-yl]piperidin-4-yl}ethyl)acetamide
• 英文别名: N-[2-[1-(4-naphthalen-2-ylpyrimidin-2-yl)piperidin-4-yl]ethyl]acetamide
• CAS: 1123234-41-2
• 化学式: C₂₃H₂₆N₄O
• 分子量: 374.486
• InChiKey: NHFVLAQXRZEVPM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM
  申请人：Pelletier Jeffrey Claude

  公开号：US20090054392A1

  公开（公告）日：2009-02-26

  The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-β-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.

  本发明涉及萘基嘧啶类似物、制备萘基嘧啶类似物的方法、包含萘基嘧啶类似物的组合物以及治疗与经典Wnt-β-catenin细胞信息传递系统相关的疾病的方法，包括向需要治疗的受试者投予有效量的萘基嘧啶、萘基吡嗪和萘基吡啶类似物。
• IMPROVEMENTS RELATING TO FABRIC TREATMENT COMPOSITIONS COMPRISING SEQUESTRANTS AND DISPERSANTS
  申请人：Unilever Plc, A Company Registered In England And Wales under company no. 41424 of Unilever House

  公开号：EP2190964A1

  公开（公告）日：2010-06-02
• [EN] NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM<br/>[FR] ANALOGUES DE NAPHTYLPYRIMIDINE, NAPHTYLPYRAZINE ET NAPHTYLPYRIDAZINE ET LEUR UTILISATION COMME AGONISTES DU SYSTÈME DE COMMUNICATION CELLULAIRE WNT-BÊTA-CATÉNINE
  申请人：WYETH CORP

  公开号：WO2009026319A1

  公开（公告）日：2009-02-26

  The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-[beta-symbol]-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.
• [EN] NAPHTHYLPYRIMIDINE, NAPHTHYLPYRAZINE AND NAPHTHYLPYRIDAZINE ANALOGS AND THEIR USE AS AGONISTS OF THE WNT-BETA-CATENIN CELLULAR MESSAGING SYSTEM<br/>[FR] ANALOGUES DE LA NAPHTHYLPYRIMIDINE, DE LA NAPHTHYLPYRAZINE ET DE LA NAPHTHYLPYRIDAZINE ET LEUR UTILISATION EN TANT QU'AGONISTES DU SYSTÈME DE MESSAGERIE CELLULAIRE WNT-BÊTA-CATÉNINE
  申请人：WYETH CORP

  公开号：WO2009026326A1

  公开（公告）日：2009-02-26

  The present invention relates to naphthylpyrimidine analogs, methods of making naphthylpyrimidine analogs, compositions comprising a naphthylpyrimidine analog, and methods for treating canonical Wnt-[beta-symbol]-catenin cellular messaging system-related disorders comprising administering to a subject in need thereof an effective amount of a naphthylpyrimidine, naphthylpyrazine and naphthylpyridazine analog.
• [EN] IMPROVEMENTS RELATING TO FABRIC TREATMENT COMPOSITIONS COMPRISING SEQUESTRANTS AND DISPERSANTS<br/>[FR] AMÉLIORATIONS RELATIVES À DES COMPOSITIONS DE TRAITEMENT DES TISSUS COMPRENANT DES SÉQUESTRANTS ET DES DISPERSANTS
  申请人：UNILEVER PLC

  公开号：WO2009040175A1

  公开（公告）日：2009-04-02

  The invention relates to a method of conferring an improved whiteness benefit to a white textile article during a laundry process, comprising the steps of: a) provision of an aqueous liquor comprising a laundry treatment composition which comprises a florescent whitening agent and an active agent, and, b) contacting the white textile article with the aqueous liquor of (a); characterised in that the active agent comprises: i) a transition metal cation sequestrant; and, ii) a dispersant which comprises one or more of naphthalene sulphonate-formaldehyde condensates, acrylic polymers, sulphonated styrene/maleic anhydride copolymers or a mixture thereof; and, that the white textile article is first contacted with the laundry treatment composition comprising the active agent during a wash step, and is further contacted with active agent made available from a different and separate rinse-added laundry treatment composition.