4-(3-bromonaphthalen-1-yl)-1-[4-methyl-1-(3,4-methylenedioxybenzyl)-1H-imidazol-5-ylmethyl]-3-(4-methylpiperazin-1-yl)carbonyl-1H-pyrrole | 303779-00-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(3-bromonaphthalen-1-yl)-1-[4-methyl-1-(3,4-methylenedioxybenzyl)-1H-imidazol-5-ylmethyl]-3-(4-methylpiperazin-1-yl)carbonyl-1H-pyrrole
• 英文别名: [1-[[3-(1,3-Benzodioxol-5-ylmethyl)-5-methylimidazol-4-yl]methyl]-4-(3-bromonaphthalen-1-yl)pyrrol-3-yl]-(4-methylpiperazin-1-yl)methanone
• CAS: 303779-00-2
• 化学式: C₃₃H₃₂BrN₅O₃
• 分子量: 626.553
• InChiKey: ZOMVEVZREXIVRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  42
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  64.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• EP1169320A4
  申请人：——

  公开号：EP1169320A4

  公开（公告）日：2002-10-30
• FARNESYL TRANSFERASE INHIBITORS HAVING A PYRROLE STRUCTURE AND PROCESS FOR PREPARATION THEREOF
  申请人：LG Chem Investment, Ltd.

  公开号：EP1169320B1

  公开（公告）日：2004-09-22
• US6511978B1
  申请人：——

  公开号：US6511978B1

  公开（公告）日：2003-01-28
• [EN] FARNESYL TRANSFERASE INHIBITORS HAVING A PYRROLE STRUCTURE AND PROCESS FOR PREPARATION THEREOF<br/>[FR] INHIBITEURS DE LA FARNESYL-TRANSFERASE AYANT UNE STRUCTURE PYRROLE ET LEUR PREPARATION
  申请人：LG CHEMICAL LTD

  公开号：WO2000064891A1

  公开（公告）日：2000-11-02

  The present invention relates to a novel pyrrole derivative which shows an inhibitory activity against farnesyl transferase or pharmaceutically acceptable salts or isomers thereof; to a process for preparation of said compound; and to a pharmaceutical composition such as anti-cancer composition, etc. comprising said compound as an active ingredient together with pharmaceutically acceptable carrier.