1-(1,1-difluoroethyl)-1-ethynylcyclopropane | 2228653-25-4

• 分子结构分类: 有机化合物 - 乙炔化物
• 英文名称: 1-(1,1-difluoroethyl)-1-ethynylcyclopropane
• CAS: 2228653-25-4
• 化学式: C₇H₈F₂
• 分子量: 130.137
• InChiKey: LLOFQCIHTXMKFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(1,1-difluoroethyl)-1-ethynylcyclopropane 、 6-bromo-1-(6-fluoro-1-methylpyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5-yl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepine 在 9-{[5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl]diphenyl-λ⁴-phosphanyl}-O-methanesulfonyl-8-methyl-8λ⁴-aza-9-palladatricyclo[8.4.0.0^2,7]tetradeca-1(14),2,4,6,10,12-hexaene-9,9-bis(ylium)-10-uid-9-olate 、 caesium carbonate 作用下， 以 乙腈 为溶剂， 生成 6-((1-(1,1-difluoroethyl)cyclopropyl)ethynyl)-1-(6-fluoro-1-methylpyrido[4,3-e][1,2,4]triazolo[4,3-a]pyrimidin-5-yl)-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepine
  参考文献：
  名称：

  [EN] DIACYLGLYERCOL KINASE MODULATING COMPOUNDS
  [FR] COMPOSÉS DE MODULATION DE LA DIACYLGLYCÉROL KINASE

  摘要：

  The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

  公开号：

  WO2022271650A1

文献信息

• [EN] DIACYLGLYCEROL KINASE MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULANT LA DIACYLGLYCÉROL KINASE
  申请人：CARNA BIOSCIENCES INC

  公开号：WO2021130638A1

  公开（公告）日：2021-07-01

  The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.

  本公开提供了调节二酰基甘油激酶的化合物以及用于治疗癌症（包括实体瘤）和病毒感染（如HIV或乙型肝炎病毒感染）的药物组合物。这些化合物可以单独使用或与其他药物联合使用。
• [EN] DIACYLGLYERCOL KINASE MODULATING COMPOUNDS<br/>[FR] COMPOSÉS MODULANT LES DIACYLGLYCÉROL KINASES
  申请人：GILEAD SCIENCES INC

  公开号：WO2022271684A1

  公开（公告）日：2022-12-29

  The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents formula (I).

  该申请涉及一般式（I）的二酰基甘油酰基激酶调节化合物及其制药组合物，用于治疗癌症，包括实体肿瘤和病毒感染，如HIV或乙型肝炎病毒感染。这些化合物可以单独使用或与其他I类药物联合使用。
• DIACYLGLYCEROL KINASE MODULATING COMPOUNDS
  申请人：GILEAD SCIENCES, INC.

  公开号：US20220324866A1

  公开（公告）日：2022-10-13

  The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.