7-methoxy-1,2,3,4-tetrahydrodibenzo[b,d]furan | 51201-47-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: 7-methoxy-1,2,3,4-tetrahydrodibenzo[b,d]furan
• 英文别名: 7-methoxy-1,2,3,4-tetrahydrodibenzofuran；7-methoxy-1,2,3,4-tetrahydro-dibenzofuran；7-Methoxy-1.2.3.4-tetrahydro-dibenzofuran
• CAS: 51201-47-9
• 化学式: C₁₃H₁₄O₂
• 分子量: 202.253
• InChiKey: MTBGXMWOHXOKSK-UHFFFAOYSA-N

物化性质

• 沸点：
  321.5±37.0 °C(Predicted)
• 密度：
  1.141±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  22.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(3-Methoxyphenoxy)cyclohexan-1-one 在 gallium(III) triflate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以101 mg的产率得到7-methoxy-1,2,3,4-tetrahydrodibenzo[b,d]furan
  参考文献：
  名称：

  Ga（OTf）3介导的取代苯并呋喃的合成

  摘要：

  合成过程中，进行了一系列官能化的苯并呋喃的合成3 - 5个benzonaphthofurans 6，从α-溴代的分子间O-烷基化起始酮2与氢的氧化酚1，随后被Ga（OTF）3的催化的分子内的直接环化脱水已经开发了所得的α-芳氧基芳基酮。研究了各种金属三氟甲磺酸酯的使用，以实现简便的方法和有效的转化。通过5的光解法制备了五环二苯并呋喃7。

  DOI：

  10.1016/j.tet.2016.07.007

文献信息

• Dehydrative C–H Alkylation and Alkenylation of Phenols with Alcohols: Expedient Synthesis for Substituted Phenols and Benzofurans
  作者：Dong-Hwan Lee、Ki-Hyeok Kwon、Chae S. Yi

  DOI：10.1021/ja302710v

  日期：2012.5.2

  well-defined cationic Ru-H complex catalyzes the dehydrative C-H alkylation reaction of phenols with alcohols to form ortho-substituted phenol products. Benzofuran derivatives are efficiently synthesized from the dehydrative C-H alkenylation and annulation reaction of phenols with 1,2-diols. The catalytic C-H coupling method employs cheaply available phenols and alcohols, exhibits a broad substrate scope, tolerates

  明确定义的阳离子 Ru-H 络合物催化苯酚与醇的脱水 CH 烷基化反应，形成邻位取代的苯酚产物。苯并呋喃衍生物是由苯酚与 1,2-二醇的脱水 CH 烯基化和环化反应有效合成的。催化 CH 偶联方法使用廉价的酚类和醇类，表现出广泛的底物范围，耐受羰基和胺官能团，并释放水作为唯一的副产物。
• Cascade Palladium-Catalyzed Direct Intramolecular Arylation/Alkene Isomerization Sequences: Synthesis of Indoles and Benzofurans
  作者：Myriam Yagoubi、Ana C. F. Cruz、Paula L. Nichols、Richard L. Elliott、Michael C. Willis

  DOI：10.1002/anie.201004097

  日期：2010.10.18

  One route, two cycles: A palladium‐catalyzed intramolecular direct arylation reaction combined with an isomerization step provided a straightforward synthetic route to both indoles and benzofurans (see scheme). Isolation and functionalization of intermediate alkene isomers allowed the formation of variants having substituents remote from the core.

  一种途径，两个循环：钯催化的分子内直接芳基化反应与异构化步骤相结合，提供了直接合成吲哚和苯并呋喃的途径（参见方案）。中间烯烃异构体的分离和官能化允许形成具有远离核的取代基的变体。
• SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF
  申请人：CAO Bin

  公开号：US20100075994A1

  公开（公告）日：2010-03-25

  The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

  本发明涉及一系列取代二氢和四氢噁唑嘧啶酮，具体地说，涉及一系列式(I)的2-取代-2,3-二氢-噁唑并[3,2-a]嘧啶-7-酮和2-取代-2,3,5,6-四氢-噁唑并[3,2-a]嘧啶-7-酮： 其中p、n、X、Y、R1、R2、R3、R4、R5、R6、R7和R8如本文所定义。本发明还涉及制备这些化合物的方法，包括新颖的中间体。本发明的化合物是代谢型谷氨酸受体（mGluR）的调节剂，特别是mGluR2受体。因此，本发明的化合物在药物制剂中具有用途，特别是在治疗和/或预防各种中枢神经系统疾病（CNS）方面，包括但不限于急性和慢性神经退行性疾病、精神病、癫痫、焦虑、抑郁、偏头痛、疼痛、睡眠障碍和呕吐。
• Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof
  申请人：Cao Bin

  公开号：US08642603B2

  公开（公告）日：2014-02-04

  The present invention relates to a series of substituted dihydro and tetrahydro oxazolopyrimidinones, specifically, to a series of 2-substituted-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-ones and 2-substituted-2,3,5,6-tetra-hydro-oxazolo[3,2-a]pyrimidin-7-ones of formula (I): Wherein p, n, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. This invention also relates to methods of making these compounds including novel intermediates. The compounds of this invention are modulators of metabotropic glutamate receptors (mGluR), particularly, mGluR2 receptor. Therefore, the compounds of this invention are useful as pharmaceutical agents, especially in the treatment and/or prevention of a variety of central nervous system disorders (CNS), including but not limited to acute and chronic neurodegenerative conditions, psychoses, convulsions, anxiety, depression, migraine, pain, sleep disorders and emesis.

  本发明涉及一系列取代的二氢和四氢噁唑嘧啶酮，具体地说，涉及一系列式(I)的2-取代-2,3-二氢噁唑并[3,2-a]嘧啶-7-酮和2-取代-2,3,5,6-四氢噁唑并[3,2-a]嘧啶-7-酮，其中p，n，X，Y，R1，R2，R3，R4，R5，R6，R7和R8如本文所定义。本发明还涉及制备这些化合物的方法，包括新的中间体。本发明的化合物是代谢型谷氨酸受体（mGluR）的调节剂，特别是mGluR2受体。因此，本发明的化合物在制药领域中有用，特别是在治疗和/或预防各种中枢神经系统疾病（CNS）方面，包括但不限于急性和慢性神经退行性疾病、精神病、惊厥、焦虑、抑郁、偏头痛、疼痛、睡眠障碍和呕吐。
• US8642603B2
  申请人：——

  公开号：US8642603B2

  公开（公告）日：2014-02-04