2-(3-isobutanoyl-6-methoxy-1H-indazol-1-yl)-N,N-dipropylethanamide | 695207-75-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 2-(3-isobutanoyl-6-methoxy-1H-indazol-1-yl)-N,N-dipropylethanamide
• 英文别名: 2-(3-Isobutyryl-6-methoxy-1H-indazol-1-yl)-N,N-dipropylacetamide；2-[6-methoxy-3-(2-methylpropanoyl)indazol-1-yl]-N,N-dipropylacetamide
• CAS: 695207-75-1
• 化学式: C₂₀H₂₉N₃O₃
• 分子量: 359.469
• InChiKey: GISCISOMNKZCGX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  64.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Ophthalmic Compositions For Treating Ocular Hypertension
  申请人：Doherty B. James

  公开号：US20080032951A1

  公开（公告）日：2008-02-07

  This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.

  本发明涉及公式（I）的有效钾通道阻滞剂化合物或其配方，用于治疗青光眼和其他导致患者眼内压升高的疾病。本发明还涉及使用这些化合物为哺乳动物眼部，特别是人类眼部提供神经保护作用。
• OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION
  申请人：Merck & Co., Inc.

  公开号：EP1771170A2

  公开（公告）日：2007-04-11
• EP1771170A4
  申请人：——

  公开号：EP1771170A4

  公开（公告）日：2009-07-08
• US7563816B2
  申请人：——

  公开号：US7563816B2

  公开（公告）日：2009-07-21
• [EN] OPHTHALMIC COMPOSITIONS FOR TREATING OCULAR HYPERTENSION<br/>[FR] COMPOSITIONS OPHTALMIQUES TRAITANT L'HYPERTENSION OCULAIRE
  申请人：MERCK & CO INC

  公开号：WO2006020003A2

  公开（公告）日：2006-02-23

  This invention relates to potent potassium channel blocker compounds of Formula (I) or a formulation thereof for the treatment of glaucoma and other conditions which leads to elevated intraoccular pressure in the eye of a patient. This invention also relates to the use of such compounds to provide a neuroprotective effect to the eye of mammalian species, particularly humans.