3-[3-(2-dimethylaminoethoxy)phenyl]propionic acid | 210304-59-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-[3-(2-dimethylaminoethoxy)phenyl]propionic acid
• 英文别名: 3-[3-[2-(Dimethylazaniumyl)ethoxy]phenyl]propanoate
• CAS: 210304-59-9
• 化学式: C₁₃H₁₉NO₃
• 分子量: 237.299
• InChiKey: VATWMVICXYULIC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  53.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• NOVEL AMIDE DERIVATIVES AND INTERMEDIATES FOR THE SYNTHESIS THEREOF
  申请人：TERUMO KABUSHIKI KAISHA

  公开号：EP0894797A1

  公开（公告）日：1999-02-03

  Novel compounds which are amide derivatives represented by general formula (I) and medicinal preparations containing the same having an eosinophilic infiltration inhibitory effect based on a potent interferon (α,γ)-inducing activity and an exellent percutaneous absorbability and being efficacious in treating allergic inflammatory diseases such as atopic dermatitis, various tumors and viral diseases. In said formula, each symbol has the following meaning: R1 and R2: each lower alkyl, etc.; X and Y: independently representing each oxygen, NR4, CR5 etc.(wherein R4 and R5 independently represent each hydrogen, an aromatic group, etc.); Z: an aromatic ring or heterocycle; R3: hydrogen, lower alkoxy, etc.; g, i and k: independently representing each an integer of from 0 to 6; h, i and l: independently representing each an integer of 0 or 1; m: an integer of from 0 to 5; and n: an integer of from 2 to 12.

  由通式(I)表示的酰胺衍生物的新型化合物以及含有这些化合物的药物制剂，它们具有基于强干扰素（α、γ）诱导活性的嗜酸性粒细胞浸润抑制作用和优异的经皮吸收性，可有效治疗过敏性炎症疾病，如特应性皮炎、各种肿瘤和病毒性疾病。在所述式中，各符号具有如下含义：R1和R2：各自代表低级烷基等；X和Y：各自独立地代表氧、NR4、CR5等（其中R4和R5各自独立地代表氢、芳香基团等）；Z：芳香环或杂环；R3：氢、低级烷氧基等；g、i和k：各自独立地代表0至6的整数；h、i和l：各自独立地代表0或1的整数；m：0至5的整数；n：2至12的整数。
• US6069149A
  申请人：——

  公开号：US6069149A

  公开（公告）日：2000-05-30