Methyl 5-iodo-2-(4-methylpiperazin-1-yl)benzoate | 1131587-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Methyl 5-iodo-2-(4-methylpiperazin-1-yl)benzoate
• CAS: 1131587-24-0
• 化学式: C₁₃H₁₇IN₂O₂
• 分子量: 360.19
• InChiKey: NZJBSHWGRVHECD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  32.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
  申请人：Nerviano Medical Sciences S.R.L.

  公开号：US20190194214A1

  公开（公告）日：2019-06-27

  Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.