prop-2-ynyloxy-[1,4]dioxane | 25306-43-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: prop-2-ynyloxy-[1,4]dioxane
• 英文别名: 2-Prop-2-ynoxy-1,4-dioxane
• CAS: 25306-43-8
• 化学式: C₇H₁₀O₃
• 分子量: 142.155
• InChiKey: ZRQFFMOAOIXXJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• NUCLEOSIDE ANALOGUE, PREPARATION METHOD AND APPLICATION
  申请人：GENEMIND BIOSCIENCES COMPANY LIMITED

  公开号：US20200283467A1

  公开（公告）日：2020-09-10

  Nucleoside or nucleotide analog compounds having the structure shown below, a method for preparing them, and applications in nucleic acid sequencing are disclosed. The compounds have formula (I): wherein L 1 , L 2 , and L 3 are each independently a covalent bond or a covalently linked group; B is a base or a base derivative selected from purines, pyrimidines, or analogs thereof; R 1 is —OH, a phosphate group, or a nucleotide; R 2 as H or a cleavable group; R 3 is a detectable group or a targeting group; R 5 is an inhibitory group; R 4 is H, —NH 2 , or —OR 6 , wherein R 6 is H or a cleavable group; and C is a cleavable group or a cleavable bond.

  揭示了具有下面所示结构的核苷酸或核苷酸类似化合物，其制备方法以及在核酸测序中的应用。这些化合物具有公式（I）：其中L1、L2和L3分别独立地是共价键或共价连接的基团；B是从嘌呤、嘧啶或其类似物中选择的碱基或碱基衍生物；R1是—OH、磷酸基团或核苷酸；R2是H或可裂解基团；R3是可检测基团或靶向基团；R5是抑制基团；R4是H、—NH2或—OR6，其中R6是H或可裂解基团；C是可裂解基团或可裂解键。
• Nucleoside analogue, preparation method and application
  申请人：GENEMIND BIOSCIENCES COMPANY LIMITED

  公开号：US11512106B2

  公开（公告）日：2022-11-29

  Nucleoside or nucleotide analog compounds having the structure shown below, a method for preparing them, and applications in nucleic acid sequencing are disclosed. The compounds have formula (I): wherein L 1 , L 2 , and L 3 are each independently a covalent bond or a covalently linked group; B is a base or a base derivative selected from purines, pyrimidines, or analogs thereof; R 1 is —OH, a phosphate group, or a nucleotide; R 2 as H or a cleavable group; R 3 is a detectable group or a targeting group; R 5 is an inhibitory group; R 4 is H, —NH 2 , or —OR 6 , wherein R 6 is H or a cleavable group; and C is a cleavable group or a cleavable bond.

  本发明公开了具有下图所示结构的核苷或核苷酸类似物化合物、其制备方法以及在核酸测序中的应用。这些化合物具有式（I）： 其中 L 1 , L 2 和 L 3 各自独立地为共价键或共价连接基团； B 是碱或碱衍生物，选自嘌呤、嘧啶或其类似物； R 1 是-OH、磷酸基团或核苷酸；R 2 为 H 或可裂解基团；R 3 是可检测基团或靶向基团；R 5 是抑制基团 4 是 H、-NH 2 或-OR 6 其中 R 6 是 H 或可裂解基团；C 是可裂解基团或可裂解键。