3-[1-(2-chloro-phenyl)-ethoxy]-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxamide | 886856-55-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 3-[1-(2-chloro-phenyl)-ethoxy]-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxamide
• 英文别名: 3-[1-(2-Chlorophenyl)ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide
• CAS: 886856-55-9
• 化学式: C₂₀H₁₆ClN₃O₂S
• 分子量: 397.885
• InChiKey: TXLCIUHAUUABEX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  97.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-[1-(2-chloro-phenyl)-ethoxy]-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxamide 生成 (R)-3-[1-(2-chlorophenyl)ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide 、 (S)-3-[1-(2-chlorophenyl)ethoxy]-5-imidazo[1,2-a]pyridin-3-ylthiophene-2-carboxamide
  参考文献：
  名称：

  NOVEL FUSED IMIDAZOLE DERIVATIVE

  摘要：

  公开号：

  EP1813613B1
• 作为产物：
  描述：

  3-[1-(2-chloro-phenyl)-ethoxy]-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxylic acid methyl ester 在 氨 作用下， 以 甲醇 为溶剂， 反应 72.0h， 以45%的产率得到3-[1-(2-chloro-phenyl)-ethoxy]-5-imidazo[1,2-a]pyridin-3-yl-thiophene-2-carboxamide
  参考文献：
  名称：

  WO2007/87283

  摘要：

  公开号：

文献信息

• Thiophene-carboxamides useful as inhibitors of protein kinases
  申请人：Brenchley Guy

  公开号：US20070219205A1

  公开（公告）日：2007-09-20

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作蛋白激酶抑制剂的化合物。本发明还提供了包含所述化合物的药学上可接受的组合物，并提供了使用该组合物治疗各种疾病、病况或疾患的方法。本发明还提供了制备发明化合物的方法。
• THIOPHENE-CARBOXAMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Brenchley Guy

  公开号：US20110288095A1

  公开（公告）日：2011-11-24

  The present invention relates to compounds useful as inhibitors of protein kinase. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The invention also provides processes for preparing compounds of the inventions.

  本发明涉及用作蛋白激酶抑制剂的化合物。本发明还提供包含该化合物的药学上可接受的组合物，并提供使用该组合物治疗各种疾病、病况或障碍的方法。本发明还提供制备本发明化合物的方法。
• Novel Fused Imidazole Derivative
  申请人：Sato Yoshiyuki

  公开号：US20080103136A1

  公开（公告）日：2008-05-01

  The present invention relates to a compound represented by the Formula [I]: Wherein: the A ring is a 5-membered aromatic heterocyclic group containing at least one hetero atom selected from a nitrogen atom, and the like; A 1 and A 2 , are each a nitrogen atom, and the like; X 2 , X 3 , X 4 , and X 5 are all carbon atoms, or alternatively any one of X 2 , X 3 , X 4 , and X 5 is a nitrogen atom and the rest are all carbon atoms; R 1 is a hydrogen atom, or the like; R 2 , R 3 , R 4 , and R 5 , are each a hydrogen atom, or the like; R 6 and R 6 ′, are each a hydrogen atom, and the like; R 7 is an aryl group and the like; and R 8 is an amino group or a hydroxy group, or a pharmaceutically acceptable salt or ester thereof.
• US7915305B2
  申请人：——

  公开号：US7915305B2

  公开（公告）日：2011-03-29
• US8030327B2
  申请人：——

  公开号：US8030327B2

  公开（公告）日：2011-10-04