1-ethyl-2,3-diphenyl-1H-inden-1-ol | 102591-69-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-ethyl-2,3-diphenyl-1H-inden-1-ol
• 英文别名: 1-ethyl-2,3-diphenyl-inden-1-ol；1-Ethyl-1-hydroxy-2,3-diphenyl-inden；1-Aethyl-2,3-diphenyl-inden-1-ol；1-Ethyl-2,3-diphenylinden-1-ol
• CAS: 102591-69-5
• 化学式: C₂₃H₂₀O
• 分子量: 312.411
• InChiKey: PZRNNTROLSYMRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-ethyl-2,3-diphenyl-1H-inden-1-ol 在 zinc(II) chloride 作用下， 生成 1-Ethyliden-2,3-diphenyl-inden
  参考文献：
  名称：

  Vallette, Annales de Chimie (Cachan, France), 1952, vol. <12> 7, p. 537,566

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯基乙炔 、 alkaline earth salt of/the/ methylsulfuric acid 以 苯 为溶剂， 反应 23.0h， 以25%的产率得到1-ethyl-2,3-diphenyl-1H-inden-1-ol
  参考文献：
  名称：

  Synthesis and reactions of [(((η6)-2-acylaryl)-C,O)tetracarbonylmanganese]-tricarbonylchromium complexes: enhancement of diastereoselection during cyclopentaannulation

  摘要：

  Cyclomanganation reactions of [(eta(6))-acylaryl]tricarbonylchromium complexes have been investigated, Three novel heterobimetallic complexes have been synthesised in moderate to good yield, with one being characterised by X-ray crystallography. Several modes of activating these bimetallic complexes towards coupling reactions with substituted alkenes and alkynes were investigated, including oxidative decarbonylation at room temperature, and thermal promotion. The stereochemistry of one of the cyclopentaannulated adducts has been established by X-ray crystallography. Thermal displacement of one of the CO ligands of the bimetallic complex 27 in the presence of PPh(3) afforded a single adduct, the structure of which was established by X-ray crystallography. The chemistry of this novel bimetallic system was investigated.

  DOI：

  10.1016/0022-328x(95)05964-q

文献信息

• Regioselective Synthesis of Indenols by Rhodium-Catalyzed CH Activation and Carbocyclization of Aryl Ketones and Alkynes
  作者：Krishnamoorthy Muralirajan、Kanniyappan Parthasarathy、Chien-Hong Cheng

  DOI：10.1002/anie.201100229

  日期：2011.4.26

  Ketones and alkynes join together: The catalytic title reaction proceeds rapidly at 120 °C and requires only 1 hour for completion (see scheme). The reaction mechanism likely involves chelation‐assisted ortho CH activation, insertion of the alkyne moiety, carbocyclization, and protonation. Cp*=pentamethylcyclopentadienyl.

  酮和炔烃结合在一起：催化标题反应在120°C下快速进行，仅需1个小时即可完成反应（请参阅方案）。反应机理可能涉及螯合辅助邻Ç  ħ活化中，炔部分，carbocyclization，和质子化的插入。Cp * ＝五甲基环戊二烯基。
• Gocmen,M. et al., Bulletin de la Societe Chimique de France, 1973, p. 562 - 569
  作者：Gocmen,M. et al.

  DOI：——

  日期：——
• Dalev et al., 1954, vol. 2, # 5, p. 19,24
  作者：Dalev et al.

  DOI：——

  日期：——