1-(4'-chlorophenylacetyl)-2-(3',4'-dichlorobenzyl)-hexahydro-1,2,4-triazine-3,5-dione | 84322-17-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4'-chlorophenylacetyl)-2-(3',4'-dichlorobenzyl)-hexahydro-1,2,4-triazine-3,5-dione
• 英文别名: 1-[2-(4-Chlorophenyl)acetyl]-2-[(3,4-dichlorophenyl)methyl]-1,2,4-triazinane-3,5-dione
• CAS: 84322-17-8
• 化学式: C₁₈H₁₄Cl₃N₃O₃
• 分子量: 426.686
• InChiKey: AZUVMDCRHLTKOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  69.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Hexahydro-1,2,4-triazine-3,5-dione derivatives and their use as feed additives
  申请人：ABIC LTD.

  公开号：EP0058534A2

  公开（公告）日：1982-08-25

  The invention provides new hexahydro-1,2,4-triazine-3,5-dione derivatives having anticoccidiastatic activity. The new derivatives are those of the general formula I: in which R3 represents a hydrogen atom; an alkyl, tetrahydrofuryl or alkylsulphonyl radical; a radical in which R4 represents an alkyl radical which is optionally substituted by a halogen atom, or by an alkoxy carbonyl or alkoxy radical; a phenyl radical substituted by one or more halogen atoms, nitro groups or lower alkyl groups; a benzyl radical substituted by one or more halogen atoms; a phenylthiomethylene or phenylaminomethylene radical substituted by one or more halogen atoms; a thienyl radical optionally substituted by one or more halogen atoms; or a CO-hexahydro-1,2,4-triazine-3,5-dione; R5 and R6 are the same or different and each represents a hydrogen atom or an alkyl group, or R6 also represents an alkali metal or alkaline earth metal atom; and A represents a group of the general formula: in which X represents one or more halogen atoms; or a group of the general formula: in which R1 and R2 are the same or different and each represents a hydrogen or halogen atom or a trifluoromethyl, alkyl, cyano or alkoxy radical; with the proviso that one ofthe substituents R1, R2, R3, R5 and R6 must be other than hydrogen. The derivatives of the invention are useful as part of a feed or a feed pre-mix or for addition to drinking water.

  本发明提供了具有抗球虫活性的新的六氢-1,2,4-三嗪-3,5-二酮衍生物。新的衍生物是通式 I 的衍生物： 其中 R3 代表一个氢原子；一个烷基、四氢糠基或烷基磺酰基；一个基团 其中 R4 代表任选被卤素原子或烷氧基羰基或烷氧基取代的烷基； 被一个或多个卤素原子、硝基或低级烷基取代的苯基； 被一个或多个卤素原子取代的苄基； 被一个或多个卤素原子取代的苯硫亚甲基或苯胺亚甲基；被一个或多个卤素原子任选取代的噻吩基；或 CO-六氢-1,2,4-三嗪-3,5-二酮； R5 和 R6 相同或不同，各自代表氢原子或烷基，或 R6 还代表碱金属或碱土金属原子；以及 A 代表通式如下的基团： 其中 X 代表一个或多个卤素原子；或通式为 其中 R1 和 R2 相同或不同，且各自代表氢原子或卤素原子或三氟甲基、烷基、氰基或烷氧基；但其中一个取代基 R1、R2、R3、R5 和 R6 必须不是氢。 本发明的衍生物可用作饲料或饲料预混料的一部分，或添加到饮用水中。
• US4426522A
  申请人：——

  公开号：US4426522A

  公开（公告）日：1984-01-17