7-tert-butylindazole | 178688-97-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 7-tert-butylindazole
• 英文别名: 7-tert-butyl-1H-indazole
• CAS: 178688-97-6
• 化学式: C₁₁H₁₄N₂
• mdl: MFCD05663435
• 分子量: 174.246
• InChiKey: RXXXLJKGIARHTE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  钾硼氢 、 7-tert-butylindazole 以 further solvent(s) 为溶剂， 生成 thallium(1+);tris(7-tert-butylindazol-2-yl)boranuide
  参考文献：
  名称：

  Hydrotris(7-tert-butylindazol-2-yl)borate: a super-hindered homoscorpionate ligand

  摘要：

  超阻碍配体氢三（7-叔丁基吲唑-2-基）硼酸盐被合成出来，并显示在形成四面体钴（II）络合物时会发生重排。

  DOI：

  10.1039/cc9960001233

文献信息

• Monoacylglycerol Lipase Modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US20200102311A1

  公开（公告）日：2020-04-02

  Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R 2 , R 3 R 4 , R 5 and R 6 are defined herein.

  桥接化合物，其结构式为(I)和(II)，包含它们的药物组合物，制造它们的方法，以及使用它们的方法，包括用于治疗与MGL调节相关的疾病状态、障碍和状况的方法，如与疼痛、精神障碍、神经障碍（包括但不限于重性抑郁障碍、难治性抑郁、焦虑性抑郁、双相情感障碍）、癌症和眼科疾病相关的方法。 其中R2、R3、R4、R5和R6的定义如下。
• PYRIDONE COMPOUNDS AND AGRICULTURAL AND HORTICULTURAL FUNGICIDES CONTAINING THE SAME AS ACTIVE INGREDIENTS
  申请人：MITSUI CHEMICALS AGRO, INC.

  公开号：US20200045968A1

  公开（公告）日：2020-02-13

  Pyridine compounds of Formula (1) are provided: wherein R1, R2, X, Y and Het are defined. The pyridine compounds can be used to treat or prevent plant diseases.

  提供了化合物的化学式（1）：其中R1、R2、X、Y和Het均已定义。这些吡啶化合物可用于治疗或预防植物疾病。
• CYSTEINE PROTEASE INHIBITORS
  申请人：Unoki Gen

  公开号：US20090291945A1

  公开（公告）日：2009-11-26

  To provide a compound having an excellent cysteine protease inhibitory effect, and to provide a drug for treatment or prevention of the disease selected from the group consisting of osteoporosis, osteoarthritis, chronic rheumatoid arthritis, Paget's disease of bone, hypercalcemia, bone metastasis of cancer, and ostealgia. A compound represented by formula (1) or a pharmaceutically acceptable salt thereof, or a drug or pharmaceutical composition containing the same as an effective component.

  提供一种具有优异半胱氨酸蛋白酶抑制作用的化合物，并提供一种用于治疗或预防骨质疏松症、骨关节炎、慢性类风湿性关节炎、骨Paget病、高钙血症、骨癌转移和骨痛的药物。化合物由式（1）表示，或其药学上可接受的盐，或将其作为有效成分的药物或药物组合物。
• Certain Heterocyclic Substituted Imidazo[1,2-A]Pyrazin-8-Ylamines And Methods Of Inhibition Of Bruton's Tyrosine Kinase By Such Compounds
  申请人：CURRIE Kevin S.

  公开号：US20080182849A1

  公开（公告）日：2008-07-31

  Compounds of Formula I and all pharmaceutically acceptable forms thereof, are described herein. The variables R 1 , R 2 , R 3 , Z 2 , and Q, shown in Formula I are defined herein. Pharmaceutical compositions containing one or more compounds of Formula I, or a pharmaceutically acceptable form of such compounds, and one or more pharmaceutically acceptable carriers, excipients, or diluents are provided herein. Methods of treating patients suffering from certain diseases responsive to inhibition of tyrosine kinase activity are also given. In certain embodiments the diseases are responsive to inhibition of Btk activity and/or B-cell proliferation. Such methods comprise administering to such patients an amount of a compound of Formula I effective to reduce signs or symptoms of the disease. These diseases include cancer, an autoimmune and/or inflammatory disease, or an acute inflammatory reaction. Thus methods of treatment include administering a sufficient amount of a compound or salt as provided herein to decrease the symptoms or slow the progression of these diseases. Other embodiments include methods of treating other animals, including livestock aid domesticated companion animals, suffering from a disease responsive to inhibition of kinase activity. Methods of treatment include administering a compound of Formula I as a single active agent or administering a compound of Formula I in combination with one or more other therapeutic agent. A method for determining the presence of Btk in a sample, comprising contacting the sample with a compound or form thereof of Formula I under conditions that permit detection of Btk activity, detecting a level of Btk activity in the sample, and therefrom determining the presence or absence of Btk in the sample.

  本文描述了公式I的化合物及其所有药用可接受形式。公式I中所示的变量R1、R2、R3、Z2和Q在此定义。本文提供了含有一个或多个公式I化合物或药用可接受形式以及一个或多个药用可接受载体、辅料或稀释剂的制药组合物。本文还提供了治疗对酪氨酸激酶活性抑制有反应的某些疾病的方法。在某些实施例中，这些疾病对Btk活性和/或B细胞增殖的抑制有反应。这些方法包括向这些患者施用足够的公式I化合物的量，以减少疾病的症状或症候。这些疾病包括癌症、自身免疫和/或炎症性疾病或急性炎症反应。因此，治疗方法包括向患者施用足够的公式或盐，以减轻这些疾病的症状或减缓其进展。其他实施例包括治疗其他动物，包括家畜和驯养的伴侣动物，患有对激酶活性抑制有反应的疾病的方法。治疗方法包括将公式I化合物作为单一活性剂或与一个或多个其他治疗剂联合使用。一种用于确定样品中Btk存在的方法，包括将样品与公式I化合物或其形式接触，以便在允许检测Btk活性的条件下检测样品中的Btk活性，并从中确定样品中Btk的存在或不存在。
• Substituted imidazoles as bombesin receptor subtype-3 modulators
  申请人：Dobbelaar Peter H.

  公开号：US20100204236A1

  公开（公告）日：2010-08-12

  Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.

  某些新型取代咪唑是人类炸弹肽受体的配体，特别是人类炸弹肽受体亚型-3（BRS-3）的选择性配体。因此，它们可用于治疗、控制或预防对BRS-3调节敏感的疾病和障碍，例如肥胖症和糖尿病。