[Cu(hyd)(phen)(acn)(ClO₄)](ClO₄) | 1400913-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: [Cu(hyd)(phen)(acn)(ClO₄)](ClO₄)
• 英文别名: [Cu(2-furoic acid hydrazide)(1,10-phenanthroline)(acetonitrile)(ClO₄)](ClO₄)
• CAS: 1400913-13-4
• 化学式: C₁₉H₁₆ClCuN₅O₆*ClO₄
• 分子量: 608.816
• InChiKey: XTLZBPBXPJQADD-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
  None
• 氢给体数：
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• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-呋喃甲酰肼 、 1,10-菲罗啉 、 copper(II) perchlorate hexahydrate 、 乙腈 以46%的产率得到[Cu(hyd)(phen)(acn)(ClO₄)](ClO₄)
  参考文献：
  名称：

  Correlation between DNA interactions and cytotoxic activity of four new ternary compounds of copper(II) with N-donor heterocyclic ligands

  摘要：

  Four new ternary complexes of copper(II) were synthesized and characterized: [Cu(hyd)(bpy)(acn)(ClO4)](ClO4)] (1), [Cu(hyd)(phen)(acn)(ClO4)](ClO4)] (2), [Cu(Shyd)(bpy)(acn)(ClO4)](ClO4)] (3) and [Cu(Shyd)(phen)(acn)(ClO4)](ClO4)] (4), in which acn=acetonitrile; hyd=2-furoic acid hydrazide, bpy=2,2-bipyridine; phen=1,10-phenanthroline and Shyd=2-thiophenecarboxylic acid hydrazide. The cytotoxic activity of the complexes in a chronic myelogenous leukemia cell line was investigated. All complexes are able to enter cells and inhibit cellular growth in a concentration-dependent manner, with an activity higher than that of the corresponding free ligands. The substitution of Shyd for hyd increases the activity, while the substitution of bpy for phen renders the complex less active. Therefore, the most potent complex is 4 with an IC50 value of 1.5±0.2μM. The intracellular copper concentration needed to inhibit 50% of cell growth is approximately 7×10(-15)mol/cell. It is worth notifying that a correlation between cytotoxic activity, DNA binding affinity and DNA cleavage was found: 1<3<2<4.

  DOI：

  10.1016/j.jinorgbio.2013.09.014