1H-3,4-dimethylindazol | 16640-81-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 1H-3,4-dimethylindazol
• 英文别名: 3,4-Dimethyl-indazol；3,4-dimethyl-1(2)H-indazole；3,4-Dimethyl-1h-indazole；3,4-dimethyl-2H-indazole
• CAS: 16640-81-6
• 化学式: C₉H₁₀N₂
• 分子量: 146.192
• InChiKey: MDGJXILRNQXOJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• PYRIMIDINE DERIVATIVES
  申请人：Kettle Jason Grant

  公开号：US20110046108A1

  公开（公告）日：2011-02-24

  The invention concerns benzamide compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R 1 , ring A, n, R 3 , and R 4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4, and/or EphA2 and/or Src kinases.

  这项发明涉及Formula (I)的苯甲酰胺化合物或其药用可接受的盐，其中R1、环A、n、R3和R4如描述中所定义。本发明还涉及制备这种化合物的方法、含有它们的药物组合物以及它们在制造用作抗增殖剂的药物中的用途，用于预防或治疗对EphB4、EphA2和/或Src激酶抑制敏感的肿瘤或其他增殖病症。
• [EN] CAPSID INHIBITORS FOR THE TREATMENT OF HIV<br/>[FR] INHIBITEURS DE CAPSIDE POUR LE TRAITEMENT DU VIH
  申请人：GILEAD SCIENCES INC

  公开号：WO2021262990A1

  公开（公告）日：2021-12-30

  The present disclosure relates generally to certain compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of a Retroviridae viral infection, including an infection caused by the HIV virus.

  本公开涉及一些化合物，包括所述化合物的药物组合物，以及制备和使用所述化合物和药物组合物的方法。本文披露的化合物和组合物可用于治疗或预防Retroviridae病毒感染，包括由HIV病毒引起的感染。
• SULTAM DERIVATIVES
  申请人：MAEKAWARA Naomi

  公开号：US20090192154A1

  公开（公告）日：2009-07-30

  A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mammalian animal including human, and is useful, for example, as an active ingredient of a pharmaceutical agent for preventing and/or treating various diseases caused by degradation of aggrecan.

  提供一种以下式（1）描述的磺酰胺衍生物，具有对聚集素酶活性的抑制作用。该式（1）的磺酰胺衍生物及其盐在哺乳动物包括人类的活体内表现出对聚集素酶活性的强抑制作用，并且可用作制药剂的活性成分，用于预防和/或治疗由聚集素降解引起的各种疾病。
• Indazoles Used To Treat Estrogen Receptor Beta Mediated Disorders
  申请人：Johnson Christopher Norbert

  公开号：US20100087502A1

  公开（公告）日：2010-04-08

  The present invention relates to novel indazole derivatives having pharmacological activity, processes for their preparation, compositions containing them and uses of these compounds in the treatment of estrogen receptor beta mediated diseases.

  本发明涉及具有药理活性的新型吲唑衍生物，其制备过程，包含它们的组成物和这些化合物在治疗雌激素受体β介导的疾病中的用途。
• AMINOPYRAZINE ANALOGS FOR TREATING GLAUCOMA AND OTHER RHO KINASE-MEDIATED DISEASES AND CONDITIONS
  申请人：Hellberg Mark R.

  公开号：US20100216777A1

  公开（公告）日：2010-08-26

  Methods for using aminopyrazine analogs to treat rho kinase-mediated diseases or rho kinase-mediated conditions, including controlling intraocular pressure and treating glaucoma, are disclosed. Ophthalmic pharmaceutical compositions useful in the treatment of eye diseases such as glaucoma, and additionally useful for controlling intraocular pressure, the compositions comprising an effective amount of aminopyrazine analogs, are also disclosed.

  本发明揭示了使用氨基吡嗪类似物治疗rho激酶介导的疾病或rho激酶介导的情况的方法，包括控制眼内压和治疗青光眼。本发明还揭示了用于治疗眼病，如青光眼，并且还有助于控制眼内压的眼科制药组合物，该组合物包括有效量的氨基吡嗪类似物。