(Z)-oxido-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]imino-pyrrolidin-1-ylazanium | 1075203-58-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: (Z)-oxido-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]imino-pyrrolidin-1-ylazanium
• CAS: 1075203-58-5
• 化学式: C₁₆H₂₃N₅O₃
• 分子量: 333.39
• InChiKey: RHYPTXMJJJVQJK-FXBPSFAMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  77.1
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-氯-1-(4-苯基哌唑)乙酮 、 sodium 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate 在 sodium carbonate 作用下， 以 六甲基磷酰三胺 为溶剂， 反应 72.0h， 生成 (Z)-oxido-[2-oxo-2-(4-phenylpiperazin-1-yl)ethoxy]imino-pyrrolidin-1-ylazanium
  参考文献：
  名称：

  NO-donors. Part 171: Synthesis and antimicrobial activity of novel ketoconazole–NO-donor hybrid compounds

  摘要：

  Novel hybrid compounds combining the antifungal drug ketoconazole with a diazen-1-ium-1,2-diolate or an organic nitrate moiety and the corresponding NO-donors without ketoconazole were synthesized and their activities against a broad variety of fungal strains were tested. Hybridization modifies the spectrum of antimicrobial activities and generally, the ketoconazole-NO-donor hybrids are more potent than ketoconazole. The NO-donors alone show insufficient effectiveness. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.05.008

文献信息

• NO-donors. Part 171: Synthesis and antimicrobial activity of novel ketoconazole–NO-donor hybrid compounds
  作者：Joerg Konter、Ute Möllmann、Jochen Lehmann

  DOI：10.1016/j.bmc.2008.05.008

  日期：2008.9

  Novel hybrid compounds combining the antifungal drug ketoconazole with a diazen-1-ium-1,2-diolate or an organic nitrate moiety and the corresponding NO-donors without ketoconazole were synthesized and their activities against a broad variety of fungal strains were tested. Hybridization modifies the spectrum of antimicrobial activities and generally, the ketoconazole-NO-donor hybrids are more potent than ketoconazole. The NO-donors alone show insufficient effectiveness. (C) 2008 Elsevier Ltd. All rights reserved.