Burixafor | 1191448-17-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: Burixafor
• 英文别名: 2-[4-[6-amino-2-[[4-[[3-(cyclohexylamino)propylamino]methyl]cyclohexyl]methylamino]pyrimidin-4-yl]piperazin-1-yl]ethylphosphonic acid
• CAS: 1191448-17-5
• 化学式: C₂₇H₅₁N₈O₃P
• 分子量: 566.727
• InChiKey: QLVSJMZJSABWRX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  39
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  152
• 氢给体数：
  6
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  在 溶剂黄146 作用下， 以 水 为溶剂， 生成 Burixafor
  参考文献：
  名称：

  LYOPHILIZATION FORMULATION

  摘要：

  这项发明涉及一种药物工具包，其中包含本说明书中描述的嘧啶化合物的冻干制剂。还公开了制备该制剂的冻干化过程。

  公开号：

  US20100120719A1

文献信息

• Heterocyclic Compounds
  申请人：Yen Chi-Feng

  公开号：US20090264339A1

  公开（公告）日：2009-10-22

  This invention relates to heterocyclic compounds of the formulas shown in the specification. It also relates to methods for treating inflammatory diseases or immune diseases, developmental or degenerative diseases, and tissue injuries with one of the heterocyclic compounds.

  这项发明涉及规范中所示的异环化合物。它还涉及使用其中一种异环化合物治疗炎症性疾病或免疫性疾病、发育性或退行性疾病以及组织损伤的方法。
• METHODS OF TREATING CASTRATE-RESISTANT PROSTATE CANCER
  申请人：Fondazione Per L'Istituto Oncologico Di Ricerca (IOR)

  公开号：EP3917568A1

  公开（公告）日：2021-12-08
• CONJUGATES FOR DELIVERING AN ANTI-CANCER AGENT TO NERVE CELLS, METHODS OF USE AND METHODS OF MAKING THEREOF
  申请人：Manzanita Pharmaceuticals, Inc.

  公开号：US20210147499A1

  公开（公告）日：2021-05-20

  Conjugates for delivering an anti-cancer agent to nerve cells are provided. Conjugate compounds of the present disclosure according to certain embodiments include a compound having a protein, peptide or pepetidomimetic that binds selectively to a neurotrophin receptor, an anti-cancer agent and a linker that covalently bonds the anti-cancer agent to the protein, peptide or pepetidomimetic binds selectively to the neurotrophin receptor. Compositions and methods for delivering an anti-cancer agent selectively into nerve cells (e.g., in the treatment of optic pathway glioma) as well as indications such as perineural invasion and skin cancers are also described. Also provided are methods of making the anti-cancer conjugate compounds.
• US8372849B2
  申请人：——

  公开号：US8372849B2

  公开（公告）日：2013-02-12
• US9023834B2
  申请人：——

  公开号：US9023834B2

  公开（公告）日：2015-05-05