2-{1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl}-N-(pyridin-4-yl)-5-(2,2,2-trifluoroethoxy)pyrimidin-4-amine | 1429746-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡唑类
• 英文名称: 2-{1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl}-N-(pyridin-4-yl)-5-(2,2,2-trifluoroethoxy)pyrimidin-4-amine
• 英文别名: US10266548, Example 11-2；2-[1-[(4-ethoxy-2,6-difluorophenyl)methyl]indazol-3-yl]-N-pyridin-4-yl-5-(2,2,2-trifluoroethoxy)pyrimidin-4-amine
• CAS: 1429746-36-0
• 化学式: C₂₇H₂₁F₅N₆O₂
• 分子量: 556.495
• InChiKey: SAKGWMPCSFXOGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  40
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  87
• 氢给体数：
  1
• 氢受体数：
  12

文献信息

• [EN] SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES.<br/>[FR] BENZYLINDAZOLES SUBSTITUÉS POUR L'UTILISATION EN TANT QU'INHIBITEURS DE BUB1 KINASE DANS LE TRAITEMENT DE MALADIES D'HYPERPROLIFÉRATION
  申请人：BAYER PHARMA AG

  公开号：WO2013050438A1

  公开（公告）日：2013-04-11

  Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.

  式(I)的化合物是Bub1激酶的抑制剂，其生产过程以及它们作为药物的用途。
• SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES
  申请人：Bayer Intellectual Property GmbH

  公开号：US20140249133A1

  公开（公告）日：2014-09-04

  Compounds of formula (I) which are inhibitors of Bub1 kinase, processes for their production and their use as pharmaceuticals.

  式(I)的化合物是Bub1激酶的抑制剂，其制备过程及其用作药物的方法。
• Substituted benzylindazoles for use as Bub1 kinase inhibitors in the treatment of hyperproliferative diseases
  申请人：Bayer Intellectual Property GmbH

  公开号：US10266548B2

  公开（公告）日：2019-04-23

  Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.

  作为 Bub 1 激酶抑制剂的式 (I) 化合物、其生产工艺及其制药用途。
• Substituted benzylindazoles for use as BUB1 kinase inhibitors in the treatment of hyperproliferative diseases
  申请人：Bayer Intellectual Property GmbH

  公开号：US10604532B2

  公开（公告）日：2020-03-31

  Compounds of formula (I) which are inhibitors of Bub 1 kinase, processes for their production and their use as pharmaceuticals.

  作为 Bub 1 激酶抑制剂的式 (I) 化合物、其生产工艺及其制药用途。
• SUBSTITUTED BENZYLINDAZOLES FOR USE AS BUB1 KINASE INHIBITORS IN THE TREATMENT OF HYPERPROLIFERATIVE DISEASES.
  申请人：Bayer Pharma Aktiengesellschaft

  公开号：EP2763982B1

  公开（公告）日：2018-01-10