(2S)-2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]propionic acid | 552330-49-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: (2S)-2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]propionic acid
• 英文别名: (2S)-2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]propanoic acid
• CAS: 552330-49-1
• 化学式: C₁₃H₁₈O₅
• 分子量: 254.283
• InChiKey: YAGYPWCBCVTRPU-LBPRGKRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S)-2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]propionic acid 、 乙醇 在 硫酸 作用下， 反应 3.0h， 以68%的产率得到(2S)-2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]propionic acid ethyl ester
  参考文献：
  名称：

  WO2008/10238

  摘要：

  公开号：
• 作为产物：
  描述：

  [(2S),N(1S)]-2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]-N-(2-hydroxy-1-phenylethyl)propionamide 在 硫酸 、 水 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以100%的产率得到(2S)-2-ethoxy-3-[4-(2-hydroxyethoxy)phenyl]propionic acid
  参考文献：
  名称：

  WO2008/10238

  摘要：

  公开号：

文献信息

• Novel compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
  申请人：Das Kumar Saibal

  公开号：US20050096331A1

  公开（公告）日：2005-05-05

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.

  本发明涉及新型抗糖尿病、降脂、抗肥胖和降胆固醇化合物，它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。更具体地，本发明涉及一般式(I)的新型烷基羧酸、它们的衍生物、类似物、互变异构体、立体异构体、多晶形态、药学上可接受的盐、药学上可接受的溶剂和含有它们的药学上可接受的组合物。
• [EN] NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES ET LEUR UTILISATION EN MEDECINE, PROCEDE DE PREPARATION DE CEUX-CI ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：REDDYS LAB LTD DR

  公开号：WO2003053974A1

  公开（公告）日：2003-07-03

  The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. More particularly, the present invention relates to novel alkyl carboxylic acids of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them.
• [EN] NOVEL ANTIDIABETIC COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS ANTIDIABÉTIQUES
  申请人：LUPIN LTD

  公开号：WO2008010238A2

  公开（公告）日：2008-01-24

  [EN] The present invention provides novel compounds of the general formula (I), wherein the symbols are same as described in specification, their pharmaceutically acceptable salts, their tautomeric forms, their stereoisomers, pharmaceutical compositions containing them, to process and intermediates for the preparation of the above said compounds, having the utility of these compounds in medicine and to methods for their therapeutic use, and their use in the treatment of diabetes and related diseases.
  [FR] L'invention porte sur de nouveaux composés antidiabétiques de formule générale (I) à usage médical dont les symboles sont définis dans la description, sur leurs sels pharmacocompatibles, sur leurs formes tautomères, sur leurs stéréoisomères, sur des préparations pharmaceutiques les contenant, sur leur procédé et leurs intermédiaires de fabrication, et sur leurs méthodes d'utilisation à des fins thérapeutiques pour le traitement du diabète de maladies associées.
• WO2008/10238
  申请人：——

  公开号：——

  公开（公告）日：——