tajixanthone ethanolate | 1173916-19-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: tajixanthone ethanolate
• 英文别名: (1R,2S)-8-[(2S)-3-ethoxy-2-hydroxy-3-methylbutyl]-1,11-dihydroxy-5-methyl-2-prop-1-en-2-yl-2,3-dihydro-1H-pyrano[3,2-a]xanthen-12-one
• CAS: 1173916-19-2
• 化学式: C₂₇H₃₂O₇
• 分子量: 468.547
• InChiKey: OHGILYFGAZVMFG-BVZALQNUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  105
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  tajixanthone 、 乙醇 在 硫酸 、 水 作用下， 反应 18.0h， 以44.8%的产率得到tajixanthone ethanolate
  参考文献：
  名称：

  Prenylxanthones and a Bicyclo[3.3.1]nona-2,6-diene Derivative from the Fungus Emericella rugulosa

  摘要：

  Five new prenylxanthones, ruguloxanthones A-C (1-3), 14-methoxytajixanthone (4), and tajixanthone ethanoate (5), a new bicyclo[3.3.1]nona-2,6-diene derivative, rugulosone: (6), and seven known compounds, shamixanthone, tajixanthone, 14-methoxytajixanthone-25-acetate, tajixanthone hydrate, tajixanthone methanoate, isoemericellin, and ergosterol, were isolated from the fungus Emericella rugulosa. The structures of 1-6 were established using spectroscopic techniques. Compound 6 exhibited antimalarial and antimycobacterial activities, as well as cytotoxicity against three cancer cell lines.

  DOI：

  10.1021/np800805f

文献信息

• Prenylxanthones and a Bicyclo[3.3.1]nona-2,6-diene Derivative from the Fungus <i>Emericella rugulosa</i>
  作者：Panawan Moosophon、Somdej Kanokmedhakul、Kwanjai Kanokmedhakul、Kasem Soytong

  DOI：10.1021/np800805f

  日期：2009.8.28

  Five new prenylxanthones, ruguloxanthones A-C (1-3), 14-methoxytajixanthone (4), and tajixanthone ethanoate (5), a new bicyclo[3.3.1]nona-2,6-diene derivative, rugulosone: (6), and seven known compounds, shamixanthone, tajixanthone, 14-methoxytajixanthone-25-acetate, tajixanthone hydrate, tajixanthone methanoate, isoemericellin, and ergosterol, were isolated from the fungus Emericella rugulosa. The structures of 1-6 were established using spectroscopic techniques. Compound 6 exhibited antimalarial and antimycobacterial activities, as well as cytotoxicity against three cancer cell lines.