2-[(aminocarbonyl)amino]-5-[4-{[(1-naphthylmethyl)amino]methyl}phenyl]thiophene-3-carboxamide | 728947-76-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[(aminocarbonyl)amino]-5-[4-{[(1-naphthylmethyl)amino]methyl}phenyl]thiophene-3-carboxamide
• 英文别名: 2-(Carbamoylamino)-5-[4-[(naphthalen-1-ylmethylamino)methyl]phenyl]thiophene-3-carboxamide
• CAS: 728947-76-0
• 化学式: C₂₄H₂₂N₄O₂S
• 分子量: 430.53
• InChiKey: ZVCKZNZOFIYTGH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  139
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme ikk-2
  申请人：Faull Wellington Alan

  公开号：US20060058522A1

  公开（公告）日：2006-03-16

  The invention relates to thiophene carboxamides of formula (I), wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的噻吩羧酰胺，其中A、R1、R2、R3、R4、R5和X如说明书中所定义，以及用于其制备的过程和中间体、含有它们的制药组合物以及它们在治疗中的使用。
• THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2
  申请人：Faull Alan Wellington

  公开号：US20100029754A1

  公开（公告）日：2010-02-04

  The invention relates to thiophene carboxamides of formula (I), wherein A, R 1 , R 2 , R 3 , R 4 , R 5 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.

  本发明涉及式(I)的噻吩羧酰胺，其中A、R1、R2、R3、R4、R5和X如规范中所定义，以及用于其制备的过程和中间体，含有它们的药物组合物以及它们在治疗中的使用。
• US7572826B2
  申请人：——

  公开号：US7572826B2

  公开（公告）日：2009-08-11