3-[3-[4-(3-Aminopropylamino)butylamino]propylsulfamoyl]-4-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate | 1160994-58-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3-[3-[4-(3-Aminopropylamino)butylamino]propylsulfamoyl]-4-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate
• CAS: 1160994-58-0
• 化学式: C₃₇H₅₄N₆O₆S₂
• 分子量: 743.004
• InChiKey: RAEZROJACHYBJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  51
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.49
• 拓扑面积：
  186
• 氢给体数：
  4
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 3-[3-[4-(3-Aminopropylamino)butylamino]propylsulfamoyl]-4-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]benzenesulfonate
  参考文献：
  名称：

  Synthesis of conjugated spermine derivatives with 7-nitrobenzoxadiazole (NBD), rhodamine and bodipy as new fluorescent probes for the polyamine transport system

  摘要：

  The synthesis of a series of conjugated spermine derivatives with benzoxadiazole, phenylxanthene or bodipy fluorophores is described. These fluorescent probes were used to identify the activity of the polyamine transport system (PTS). N-1-Methylspermine NBD conjugate 5 proved to have the optimal fluorescence characteristics and was used to show a selectivity for PTS-proficient CHO versus PTS-deficient CHO-MG cells. It can therefore be used as a tool for the selection of cells sensitive to cytotoxic compounds vectored through the PTS. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.052