Carbidopa Hydrochloride | 65132-60-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: Carbidopa Hydrochloride
• 英文别名: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid;hydrochloride
• CAS: 65132-60-7
• 化学式: C10H15ClN2O4
• 分子量: 262.69
• InChiKey: FRTJEAIOPNOZNI-PPHPATTJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  116
• 氢给体数：
  6
• 氢受体数：
  6

文献信息

• Catechol protected levodopa diester prodrugs, compositions, and methods of use
  申请人：Xiang Jia-Ning

  公开号：US20080171789A1

  公开（公告）日：2008-07-17

  Catechol protected levodopa diester prodrugs pharmaceutical, compositions comprising catechol protected levodopa diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.

  提供了一种保护左旋多巴二酯前药的制药品，包括含有保护左旋多巴二酯前药的制剂，以及利用这种前药和制药组合物治疗帕金森病等疾病的方法。
• Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use
  申请人：Xiang Jia-Ning

  公开号：US20080214663A1

  公开（公告）日：2008-09-04

  Levodopa dimethyl-substituted diester prodrugs pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.

  本文提供了左旋多巴二甲基取代二酯前药制剂、包含左旋多巴二甲基取代二酯前药制剂的药物组合物，以及使用这些前药和药物组合物治疗帕金森病等疾病的方法。
• LEVODOPA DIMETHYL-SUBSTITUTED DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE
  申请人：Xiang Jia-Ning

  公开号：US20100173992A1

  公开（公告）日：2010-07-08

  Levodopa dimethyl-substituted diester prodrugs pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.

  本发明提供了左旋多巴二甲基取代二酯前药制剂、包含左旋多巴二甲基取代二酯前药制剂的制剂组合物，以及使用这些前药制剂和制剂组合物治疗帕金森病等疾病的方法。
• CATECHOL PROTECTED LEVODOPA DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE
  申请人：Xiang Jia-Ning

  公开号：US20110028544A1

  公开（公告）日：2011-02-03

  Catechol protected levodopa diester prodrugs pharmaceutical, compositions comprising catechol protected levodopa diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.

  本文提供了儿茶酚保护的左旋多巴二酯前药制剂、包含儿茶酚保护的左旋多巴二酯前药制剂的制药组合物，以及使用这些前药和制药组合物治疗帕金森病等疾病的方法。
• Carbidopa for the treatment of cancer
  申请人：Texas Tech University System

  公开号：US10064834B2

  公开（公告）日：2018-09-04

  The present invention includes a method of inhibiting or reducing mTOR signaling or inhibition of indoleamine dioxygenase-1 (IDO1) in a subject with a proliferative disease, which comprises administering to the subject having or suspected to have the proliferative disease, a therapeutically or prophylactically effective amount of the compound of Formula I: or a pharmaceutically acceptable salt or solvate thereof.

  本发明包括一种在患有增殖性疾病的受试者中抑制或减少 mTOR 信号转导或抑制吲哚胺二氧 化酶-1（IDO1）的方法，该方法包括向患有或疑似患有增殖性疾病的受试者施用治疗或预防有效量的式 I 化合物： 或其药学上可接受的盐或溶液。