4-(2,4-dimethoxyphenyl)-6,8-dimethoxy-1,3-dihydronaphtho[2,3-c]thiophene-2,2-dioxide | 1617506-49-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(2,4-dimethoxyphenyl)-6,8-dimethoxy-1,3-dihydronaphtho[2,3-c]thiophene-2,2-dioxide
• 英文别名: 4-(2,4-Dimethoxyphenyl)-6,8-dimethoxy-1,3-dihydrobenzo[f][2]benzothiole 2,2-dioxide
• CAS: 1617506-49-6
• 化学式: C₂₂H₂₂O₆S
• 分子量: 414.479
• InChiKey: HKORNFCMKTWQCC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  在 aluminum oxide 作用下， 以 二氯甲烷 为溶剂， 以95%的产率得到4-(2,4-dimethoxyphenyl)-6,8-dimethoxy-1,3-dihydronaphtho[2,3-c]thiophene-2,2-dioxide
  参考文献：
  名称：

  Garratt–Braverman cyclization on basic alumina: a green protocol with improved selectivity

  摘要：

  A green protocol (compared to the existing methodology) for carrying out Garratt-Braverman cyclization has been developed. The method involves stirring a pre-absorbed bispropargyl sulfone/ether/sulfonamide over basic alumina. The reaction with sulfones was over within 10-15 mm at room temperature whereas for the ether/sulfonamide the reaction took 6-8 h at 130 degrees C. The products, aryl naphthalene derivatives, are obtained by simple filtration through Celite, in excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.05.033