| 1554400-49-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1554400-49-5
• 化学式: C₁₉H₂₈O₂Si
• 分子量: 316.516
• InChiKey: RDTAJWKGSJYXQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  22.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  29.46
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  在 copper (II)-fluoride 、 iron(III) chloride 、 bis(1,5-cyclooctadiene)nickel (0) 、 cesium fluoride 、 三环己基膦 作用下， 以 甲苯 为溶剂， 生成 triethyl(7-((triisopropylsilyl)oxy)naphthalen-2-yl)silane
  参考文献：
  名称：

  A Mild Ni/Cu-Catalyzed Silylation via C–O Cleavage

  摘要：

  A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or benzyl alcohols is described. This transformation is characterized by its wide scope and mild conditions, providing a direct access to synthetically versatile silylated compounds. The protocol allows for the coupling of C(sp(2))-O and even C(sp(3))-O bonds with similar efficiency.

  DOI：

  10.1021/ja412107b

文献信息

• Synthesis of benzo[<i>b</i>]furans from alkynyl sulfoxides and phenols by the interrupted Pummerer reaction
  作者：Akihiro Kobayashi、Tsubasa Matsuzawa、Takamitsu Hosoya、Suguru Yoshida

  DOI：10.1039/d2ra07856b

  日期：——

  The interrupted Pummerer reaction of alkynyl sulfoxides with phenols is disclosed. A wide range of benzo[b]furans were efficiently synthesized through unexplored electrophilic activation of the electron-deficient alkynyl sulfinyl group. Based on the good availability of alkynyl sulfoxides, we successfully prepared various functionalized benzo[b]furans from readily available alkynes, thiosulfonates

  公开了炔基亚砜与酚类的间断 Pummerer 反应。通过未探索的缺电子炔基亚磺酰基的亲电活化，有效合成了多种苯并[ b ]呋喃。基于炔基亚砜的良好可用性，我们成功地从容易获得的炔烃、硫代磺酸盐和苯酚制备了各种功能化的苯并[ b ]呋喃。