2-tert-Butoxy-1,2-bis(4-methylphenyl)ethan-1-one | 61492-62-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-tert-Butoxy-1,2-bis(4-methylphenyl)ethan-1-one
• 英文别名: 1,2-bis(4-methylphenyl)-2-[(2-methylpropan-2-yl)oxy]ethanone
• CAS: 61492-62-4
• 化学式: C₂₀H₂₄O₂
• 分子量: 296.4
• InChiKey: IZENCDDRGKNSIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] CHEMICAL COMPOUNDS<br/>[FR] COMPOSES CHIMIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2004011410A1

  公开（公告）日：2004-02-05

  Compounds of formula (I):wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  式(I)的化合物：其中变量基团如定义内；用于抑制11βHSD1。
• Indazole derivatives as JNK inhibitors and compositions and methods related thereto
  申请人：Bhagwat S. Shripad

  公开号：US20050107457A1

  公开（公告）日：2005-05-19

  Compounds having activity as selective inhibitors of JNK are disclosed. The compounds of this invention are indazole derivatives having the following structure: wherein R 1 , R 2 and A are as defined herein. Such compounds have utility in the treatment of a wide range of conditions that are responsive to JNK inhibition. Thus, methods of treating such conditions are also disclosed, as are pharmaceutical compositions containing one or more compounds of the above compounds.

  本发明揭示了具有选择性抑制JNK活性的化合物。本发明的化合物是具有以下结构的吲唑衍生物：其中R1、R2和A如本文所定义。这些化合物在治疗对JNK抑制有反应的广泛疾病方面具有实用性。因此，本发明还揭示了治疗这些疾病的方法，以及含有上述化合物中的一个或多个化合物的制药组合物。
• Ketones
  申请人：Barton John Peter

  公开号：US20050272036A1

  公开（公告）日：2005-12-08

  Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11βHSD1 are described.

  描述了式(I)的化合物：其中变量基团如定义的那样；用于抑制11βHSD1。
• KETONES
  申请人：AstraZeneca AB

  公开号：EP1549600A1

  公开（公告）日：2005-07-06