7-chloro-3-(5-chloro-2-methylphenyl)isoquinolin-1-amine | 1029008-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-chloro-3-(5-chloro-2-methylphenyl)isoquinolin-1-amine
• CAS: 1029008-62-5
• 化学式: C₁₆H₁₂Cl₂N₂
• 分子量: 303.191
• InChiKey: WPRGCUYXXPATKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 5, 6, or 7-Substituted - 3-(hetero) arylisoquinolinamine derivatives and therapeutic use thereof
  申请人：Lee Young B.

  公开号：US20080182871A1

  公开（公告）日：2008-07-31

  The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.

  本发明涉及一般公式D所代表的5,6或7-取代-3-(杂)芳基异喹啉胺衍生物及其药理学上可接受的盐，以及含有这类化合物的组合物。还包括通过给予这些化合物来治疗过度增殖性疾病的方法。
• 5, 6, or 7-SUBSTITUTED -3-(HETERO) ARYLISOQUINOLINAMINE DERIVATIVES AND THERAPEUTIC USE THEREOF
  申请人：LEE YOUNG B.

  公开号：US20120029012A1

  公开（公告）日：2012-02-02

  The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.

  本发明涉及5、6或7-取代-3-(杂)芳基异喹啉胺衍生物D的一般式，其药理学上可接受的盐以及含有这种化合物的组合物。还包括通过给予这些化合物治疗过度增殖性疾病的方法。
• 5, 6 or 7-substituted-3-phenylisoquinolinamine derivatives and therapeutic use thereof
  申请人：Rexahn Pharmaceuticals, Inc.

  公开号：EP2423196A1

  公开（公告）日：2012-02-29

  The present invention relates to 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives represented by general formula D, their pharmacologically acceptable salts thereof, and compositions containing such compounds. Methods for treating hyperproliferative disorders by administering the compounds are also included.

  本发明涉及通式 D 所代表的 5、6 或 7-取代-3-(杂)芳基异喹啉胺衍生物、其药理学上可接受的盐，以及含有此类化合物的组合物。此外，还包括通过施用这些化合物来治疗过度增殖性疾病的方法。
• 5, 6, OR 7-SUBSTITUTED-3-ARYLISOQUINOLINAMINE DERIVATIVES AS ANTITUMOR AGENTS
  申请人：Rexahn Pharmaceuticals, Inc.

  公开号：EP2099765B1

  公开（公告）日：2012-08-29
• US8034829B2
  申请人：——

  公开号：US8034829B2

  公开（公告）日：2011-10-11