| 63649-77-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• CAS: 63649-77-4
• 化学式: C13H18MgO2
• 分子量: 230.59
• InChiKey: AENZYXWIKHVNBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.69
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compound and method of treating neurogenic conditions using non-steroidal anti-inflammatory drug complexes
  申请人：Miller C.G. Landon

  公开号：US20060142181A1

  公开（公告）日：2006-06-29

  A complex is provided for the treatment of neurogenic conditions having the formula: where R 1 is M is a metal ion Ca(II), Mg(II), Cu(II) or Ni(II); n is an integer 1 or 2; R is BBB peptide, transferrin, membrane transporter peptide, TAT peptide, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptidegluconate, L-lactate, L-leucine, L-tryptophan, and L-glutamate; and R is coupled to M through a carboxylate moiety. Magnesium (II) represents the preferred metal ion as magnesium is known to have neuroprotective effects. The metal ion is in part chelated by a non-steroidal anti-inflammatory drug that does not inhibit platelet activity and includes salicylate and ibuprofenate. The complex also includes a ligand operative in transport across the blood brain barrier. A process for making an inventive complex includes the stoichiometric addition of ligands containing carboxylate groups to a solution of the metal ion. In instances where the metal ion is magnesium (II), a stoichiometric ratio of 1:1:1 is found between the non-steroidal anti-inflammatory ligand:magnesium (II):transporter ligand.

  提供了一种用于治疗神经原性疾病的复合物，其化学式为：其中，R1是M是金属离子Ca（II）、Mg（II）、Cu（II）或Ni（II）；n是整数1或2；R是BBB肽、转铁蛋白、膜转运肽、TAT肽、缓激肽、β-内啡肽、博美胰素、钙降素、胆囊收缩素、一种脑啡肽、痛阻肽、胰岛素、胃泌素、物质P、神经肽、胰高血糖素、分泌素、生长抑素、动力素、加压素、催产素、泌乳素、促甲状腺素、血管紧张素、胃泌素释放肽、L-葡萄糖酸盐、L-乳酸、L-亮氨酸、L-色氨酸和L-谷氨酸；并且R通过羧酸盐基与M偶联。镁（II）代表首选金属离子，因为镁已知具有神经保护作用。金属离子部分被非甾体抗炎药物螯合，该药物不抑制血小板活性，包括水杨酸盐和布洛芬酸盐。复合物还包括在血脑屏障转运中发挥作用的配体。制造创新复合物的过程包括将含羧酸基的配体按化学计量比加入金属离子的溶液中。在金属离子为镁（II）的情况下，非甾体抗炎配体：镁（II）：转运体配体的化学计量比为1:1:1。
• Pharmaceutical compositions containing ibuprofen-cyclodextrin complexes
  申请人：RECKITT AND COLMAN PRODUCTS LIMITED

  公开号：EP0346006A1

  公开（公告）日：1989-12-13

  Complexes of β-cyclodextrin with various salts of ibuprofen are described in which the molar ratios of ibuprofen to β-cyclodextrin are within the range of from 1:0.20 to 1:0.75. The preferred salt of ibuprofen is the sodium salt. The complexes have enhanced taste profile and bioavailability. Also disclosed are methods for preparing the complexes and also pharmaceutical compositions thereof.

  β-环糊精与布洛芬各种盐的络合物已作了描述，其中布洛芬与 β-环糊精的摩尔比在 1:0.20 至 1:0.75 之间。布洛芬的首选盐是钠盐。这种复合物具有更好的口感和生物利用度。还公开了制备复合物及其药物组合物的方法。
• US5019563A
  申请人：——

  公开号：US5019563A

  公开（公告）日：1991-05-28