6-[2-(3,5-Dimethoxyphenyl)ethenyl]-1-benzothiophene-4-ol | 832128-17-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 6-[2-(3,5-Dimethoxyphenyl)ethenyl]-1-benzothiophene-4-ol
• 英文别名: 6-[2-(3,5-dimethoxyphenyl)ethenyl]-1-benzothiophen-4-ol
• CAS: 832128-17-3
• 化学式: C₁₈H₁₆O₃S
• 分子量: 312.4
• InChiKey: KAXDUHWEDZVLIH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Combretastatin derivatives with cytotoxic action
  申请人：Giannini Giuseppe

  公开号：US20060160773A1

  公开（公告）日：2006-07-20

  The invention described herein relates to new combretastatin derivatives obtained by total synthesis and having the following general formula: in which the groups are as defined in the description here below. Said compounds, though chemically related to the structure of cis/trans-combretastatin, do not always bind tubulin, but nevertheless exhibit cytotoxic activity of interest in the oncological field as anticancer and/or antiangiogenic agents.

  本发明涉及通过全合成获得的具有以下通式的新的考布他丁衍生物： 其中各基团的定义见下文说明。上述化合物虽然在化学上与顺式/反式-考布他汀的结构有关，但并不总是与微管蛋白结合，而是作为抗癌和/或抗血管生成剂，在肿瘤领域表现出令人感兴趣的细胞毒性活性。
• COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION
  申请人：SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP1646616A2

  公开（公告）日：2006-04-19
• [EN] COMBRETASTATIN DERIVATIVES WITH CYTOTOXIC ACTION<br/>[FR] DERIVES DE LA COMBRETASTATINE A ACTION CYTOTOXIQUE
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2005007635A2

  公开（公告）日：2005-01-27

  The invention described herein relates to new combretastatin derivatives obtained by total synthesis and having the following general formula (I) in which the groups are as defined in the description here below. Said compounds, though chemically related to the structure of cis/trans-combretastatin, do not always bind tubulin, but nevertheless exhibit cytotoxic activity of interest in the oncological field as anticancer and/or antiangiogenic agents.