[Ru(bpy)₂(dipyrido[3,2-d:2′,3′-f]quinoxaline)]²⁺ | 218163-65-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: [Ru(bpy)₂(dipyrido[3,2-d:2′,3′-f]quinoxaline)]²⁺
• 英文别名: [Ru(bpy)₂(dpq)]²⁺；[Ru(2,2'-bipyridine)2(dipyrido[3,2-a:2',3'-c]phenazine)](2+)；bis(2,2'-bipyridine-κN1,κN1')(pyrazino[2,3-f][1,10]phenanthroline-κN8,κN9)ruthenium(2+)；(dipyridoquinoxaline)bis(2,2'-bipyridine)ruthenium(II)；[Ru(2,2'-bipyridine)2(pyrazino[2,3-f][1,10]phenanthroline)](2+)；[Ru(2,2'-bipyridine)2(dipyrido[3,2-d:2',3'-f]quinoxaline](2+)；[Ru(2,2'-bipyridyl)2(dipyrido[3,2-d:2',3'-f]quinoxaline)](2+)；Ru(bipyridine)2(dipyrido[3,2-a:2',3'-c]quinoxaline)(2+)；[Ru(2,2'-bipyridyl)2([3,2-d:2',3'-f]quinoxaline)](2+)；ruthenium(II)(2,2'-bipyridine)2(1,4,8,9-tetra-aza-triphenylene)；[Ru(1,4,8,9-tetra-aza-triphenylene)(2,2'-bipyridine)2](2+)；[Ru(bipy)2(tatp)](2+)
• CAS: 218163-65-6；217968-78-0；218163-64-5
• 化学式: C₃₄H₂₄N₈Ru
• 分子量: 645.688
• InChiKey: GEJTUQCQXYOEQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
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• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  吡嗪并[2，3-f]的[1，10]菲咯啉 、 顺-双(2,2-二吡啶)二氯化钌(II) 水合物 以 乙二醇 为溶剂， 生成 [Ru(bpy)₂(dipyrido[3,2-d:2′,3′-f]quinoxaline)]²⁺
  参考文献：
  名称：

  Experimental and theoretical studies on the DNA-binding and spectral properties of water-soluble complex [Ru(MeIm)4(dpq)]2+

  摘要：

  A new water-soluble Ru(II) complex [Ru(MeIm)(4)(dpq)](2+) 1, has been synthesized and characterized by elemental analysis, H-1 NMR, ESI-MS and UV-Vis. The interaction of the complex with CT-DNA has been explored by using electronic absorption titration, competitive binding experiment, circular dichroic (CD) spectra, thermal denaturation and viscosity measurements. The experimental results show that: the title complex can bind to DNA in an intercalative mode and its DNA-binding affinity is weaker (K-b = 1.2 x 10(4) m(-1)) than that of the complex [Ru(bpy)(2)(dpq)](2+) 2 with bidentate co-ligands (K-b = 4.7 x 10(4) m(-1)). Here a very interesting finding is that the hypochromism of the title complex is not linear relation to its DNA-binding affinity. In addition, some significant thermodynamic parameters of the binding of the title complex to DNA, e.g., the changes of free energy at melting temperature, standard enthalpy, and standard entropy (Delta G(T)(0), Delta H-0, and Delta S-0), were determined and calculated. In order to deeply explain the experimental findings, the DFT/TDDFT computations were carried out. On the basis of the DFT/TDDFT results and the frontier molecular orbital theory, the trend in DNA-binding affinities and the spectral properties as well as the interesting phenomena of larger extent of hypochromism but relatively smaller Kb value for the title complex 1 compared with complex 2 were reasonably explained. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2007.09.010