| 1620209-89-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1620209-89-3
• 化学式: C₂₄H₃₁ClN₈O₄S₂
• 分子量: 595.146
• InChiKey: HYBWXTTVXREMLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.29
• 重原子数：
  39.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  127.52
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  、 2-氯-5-氯甲基噻唑 在 potassium carbonate 作用下， 生成 、
  参考文献：
  名称：

  Synthesis and biological activity of fluorescent neonicotinoid insecticide thiamethoxam

  摘要：

  Here, we describe the synthesis of two new fluorescent derivatives of thiamethoxam and compared their toxicity on aphid Acyrthosiphon pisum and their mode of action on insect nicotinic acetylcholine receptors expressed on the sixth abdominal ganglion. The compound 3 with two 2-chlorothiazole moieties was found to be more toxic using toxicological bioassays 24 h and 48 h after exposure while compound 4 appeared more active using cockroach ganglionic depolarization. Interestingly, thiamethoxam appeared more effective than component 3 and 4, respectively. Our results demonstrated that component 3 and 4 act as agonists of insect nicotinic acetylcholine receptors. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2014.05.052