1-(3-(Benzo[d][1,3]dioxol-5-yloxy)propyl)-4-phenylpiperazine maleate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1-(3-(Benzo[d][1,3]dioxol-5-yloxy)propyl)-4-phenylpiperazine maleate
• 英文别名: 1-[3-(1,3-benzodioxol-5-yloxy)propyl]-4-phenylpiperazine;but-2-enedioic acid
• 化学式: C24H28N2O7
• 分子量: 456.5
• InChiKey: NBCXNOHQTALBRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.72
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Kits for classifying a subject having or at risk for developing idiopathic scoliosis
  申请人：Chu Sainte-Justine

  公开号：US10247737B2

  公开（公告）日：2019-04-02

  A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.

  一种对患有特发性脊柱侧弯症（IS）或有患 IS 风险的受试者进行分类的方法，包括：在存在 OPN 的情况下，确定受试者细胞样本中细胞对 Gi 刺激的反应；在不存在 OPN 的情况下，确定受试者细胞样本中细胞对 Gi 刺激的反应；以及将存在 OPN 时获得的细胞反应与不存在 OPN 时获得的细胞反应进行比较，其中比较步骤可将受试者分类为一个 IS 功能组。此外，还提供了使用前述方法对边缘受试者进行分类的方法和应用这些方法的试剂盒。
• Electrified compositions for determining the risk of developing adolescent idiopathic scoliosis through the use of GI protein receptor
  申请人：CHU Sainte-Justine

  公开号：US10620222B2

  公开（公告）日：2020-04-14

  Methods for diagnosing a predisposition to developing a scoliosis (e.g., adolescent idiopathic scoliosis (AIS)) and identifying compounds for treating scoliosis based on the modulation of Gi protein-coupled receptor activity are described. Specific embodiments of the methods involve measuring a change in impedance signals of cells expressing a receptor coupled to a Gi protein with a ligand. To identify compounds useful in treatment, the cell is contacted with a test compound and a ligand. A higher impedance in the presence relative to the absence of said test compound is indicative that the test compound is useful for treating scoliosis.

  本文描述了诊断脊柱侧弯症（如青少年特发性脊柱侧弯症（AIS））易患性的方法，以及根据对 Gi 蛋白偶联受体活性的调节确定治疗脊柱侧弯症的化合物的方法。这些方法的具体实施方案包括测量表达与 Gi 蛋白耦合的受体的细胞的阻抗信号变化。为了确定对治疗有用的化合物，细胞与测试化合物和配体接触。在存在所述测试化合物的情况下，阻抗比不存在时更高，这表明测试化合物有助于治疗脊柱侧弯。
• METHODS FOR THE CLASSIFICATION AND DIAGNOSIS OF SCOLIOSIS THROUGH THE USE OF GI PROTEIN RECEPTOR
  申请人：Chu Sainte-Justine

  公开号：EP2331962A1

  公开（公告）日：2011-06-15
• NEW MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS
  申请人：Chu Sainte-Justine

  公开号：EP3044321A1

  公开（公告）日：2016-07-20
• MARKER FOR THE CLASSIFICATION, DIAGNOSIS AND TREATMENT OF SCOLIOSIS
  申请人：Chu Sainte-Justine

  公开号：US20190178896A1

  公开（公告）日：2019-06-13

  A method of classifying a subject having idiopathic scoliosis (IS) or at risk of developing IS comprising: determining the cellular response to Gi stimulation in a cell sample from the subject in the presence of OPN; determining the cellular response to Gi stimulation in a cell sample from the subject in the absence of OPN; and comparing the cellular response obtained in the presence of OPN with the cellular response obtained in the absence of OPN, whereby the comparing step enables the classification of the subject into one IS functional group. Also provided is the use of the foregoing method to classify borderline subjects and kits for applying the methods.