N-((2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methyl)cyclopropanamine | 1156159-57-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并二恶烷
• 英文名称: N-((2,3-dihydrobenzo[b][1,4]dioxin-5-yl)methyl)cyclopropanamine
• 英文别名: Cyclopropyl-(2,3-dihydro-benzo[1,4]dioxin-5-ylmethyl)-amine；N-(2,3-dihydro-1,4-benzodioxin-5-ylmethyl)cyclopropanamine
• CAS: 1156159-57-7
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: KKPUSLZHVJJQHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] COMPOUNDS AS INHIBITORS OF RENIN<br/>[FR] COMPOSÉS INHIBITEURS DE RÉNINE
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2013084241A1

  公开（公告）日：2013-06-13

  The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to processes for preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及一般式（1）的新型肾素抑制剂，涉及其合成中所涉及的新型中间体，其药学上可接受的盐以及含有它们的药物组合物。本发明还涉及制备一般式（1）化合物的过程，它们的互变异构体形式，其药学上可接受的盐，含有它们的药物组合物，以及其合成中所涉及的新型中间体。
• NOVEL COMPOUNDS AS INHIBITORS OF RENIN
  申请人：Thombare Pravain

  公开号：US20120115907A1

  公开（公告）日：2012-05-10

  The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.

  本发明涉及一般式（1）的新型肾素抑制剂，其合成中涉及的新型中间体，它们的药用盐以及含有它们的药物组合物。本发明还涉及制备一般式（1）化合物的方法，它们的互变异构体形式，它们的药用盐，含有它们的药物组合物，以及合成中涉及的新型中间体。
• PIPERIDINE DERIVATIVES AS INHIBITORS OF RENIN
  申请人：Cadila Healthcare Limited

  公开号：EP2421828A2

  公开（公告）日：2012-02-29
• [EN] NOVEL COMPOUNDS AS INHIBITORS OF RENIN<br/>[FR] NOUVEAUX COMPOSÉS INHIBITEURS DE RÉNINE
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2010122580A2

  公开（公告）日：2010-10-28

  The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.
• [EN] COMPOUNDS AS INHIBITORS OF RENIN<br/>[FR] COMPOSÉS UTILISÉS COMME INHIBITEURS DE LA RÉNINE
  申请人：CADILA HEALTHCARE LTD

  公开号：WO2012085935A2

  公开（公告）日：2012-06-28

  The present invention relates to novel renin inhibitors of general formula (1), novel intermediates involved in their synthesis, their pharmaceutically acceptable salts and pharmaceutical compositions containing them. The present invention also relates to a process of preparing compounds of general formula (1), wherein all the symbols are as defined in the specification, their tautomeric forms, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and novel intermediates involved in their synthesis.