N-hydroxy-2-[(4-methylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide | 1383792-99-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢异喹啉
• 英文名称: N-hydroxy-2-[(4-methylpiperidin-4-yl)carbonyl]-1,2,3,4-tetrahydroisoquinoline-6-carboxamide
• 英文别名: N-hydroxy-2-(4-methylpiperidine-4-carbonyl)-3,4-dihydro-1H-isoquinoline-6-carboxamide
• CAS: 1383792-99-1
• 化学式: C₁₇H₂₃N₃O₃
• 分子量: 317.388
• InChiKey: CBEBORFKQDEVGQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  81.7
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF
  申请人：Gould Alexandra E.

  公开号：US20120165316A1

  公开（公告）日：2012-06-28

  This invention provides compounds of formula (I): wherein R 1 , R 2 , X, p, q, m, n, and Ring C have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.

  该发明提供了化合物的结构式（I）： 其中R1、R2、X、p、q、m、n和环C的取值如规范中所述，可用作HDAC6的抑制剂。该发明还提供了包含该发明化合物的药物组合物以及使用该组合物治疗增生性、炎症性、感染性、神经系统或心血管疾病或障碍的方法。
• US8778931B2
  申请人：——

  公开号：US8778931B2

  公开（公告）日：2014-07-15
• [EN] SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF<br/>[FR] ACIDES HYDROXAMIQUES SUBSTITUÉS ET LEURS UTILISATIONS
  申请人：MILLENNIUM PHARM INC

  公开号：WO2012088015A2

  公开（公告）日：2012-06-28

  This invention provides compounds of formula (I); wherein R1, R2, X, p, q, m, n, and Ring C have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders.