(2S)-2-[(1R,3aS,4S,7S,8aS)-1,4-dimethyl-2,8-dioxo-2,3,3a,4,8,8a-hexahydro-4,7-epidioxyazulen-7(1H)-yl]propyl acetate | 1254986-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: (2S)-2-[(1R,3aS,4S,7S,8aS)-1,4-dimethyl-2,8-dioxo-2,3,3a,4,8,8a-hexahydro-4,7-epidioxyazulen-7(1H)-yl]propyl acetate
• 英文别名: [(2S)-2-[(1S,2S,5R,6S,8S)-1,5-dimethyl-4,7-dioxo-9,10-dioxatricyclo[6.2.2.02,6]dodec-11-en-8-yl]propyl] acetate
• CAS: 1254986-33-8
• 化学式: C₁₇H₂₂O₆
• 分子量: 322.358
• InChiKey: XGUDQUQWMXAERQ-VWPMSQDYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  78.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (2S)-2-[(1R,2S,3aS,4S,7S,8aR)-2-hydroxy-8-oxy-1,4-dimethyl-2,3,3a,4,8,8a-hexahydro-4,7-epidioxyazulen-7(1H)-yl]propyl acetate 在 戴斯-马丁氧化剂 作用下， 以 二氯甲烷 为溶剂， 反应 1.08h， 以62%的产率得到(2S)-2-[(1R,3aS,4S,7S,8aS)-1,4-dimethyl-2,8-dioxo-2,3,3a,4,8,8a-hexahydro-4,7-epidioxyazulen-7(1H)-yl]propyl acetate
  参考文献：
  名称：

  Design, Synthesis, and Development of Novel Guaianolide-Endoperoxides as Potential Antimalarial Agents

  摘要：

  Design and synthesis of a guaianolide-endoperoxide (thaperoxide) 3 was pursued as a new antimalarial lead which was found to be noncytotoxic as compared to the natural product lead thapsigargin 2. Several analogues of 3 were successfully synthesized and found to be comparable to derivatives of artemisinin 1 in in vitro antimalarial assay. Among the synthesized compounds, 22 showed excellent in vitro potency against the cultured parasites (W2 IC50 = 13 nM) without apparent cytotoxicity. Furthermore, SAR trends in thaperoxide analogues are presented and explained with the help of docking studies in the homology model of PfSERCA(PfATP6).

  DOI：

  10.1021/jm1006462