4-(4-methylpiperazin-1-yl)naphthalene-1,2-dione | 188184-15-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4-(4-methylpiperazin-1-yl)naphthalene-1,2-dione
• CAS: 188184-15-8
• 化学式: C₁₅H₁₆N₂O₂
• 分子量: 256.304
• InChiKey: BMXXUHZOFGLVRS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• New compounds with antiglutamatergic properties and uses thereof
  申请人：Faust Pharmaceuticals

  公开号：EP1961738A1

  公开（公告）日：2008-08-27

  The present invention provides new compounds displaying antiglutamatergic properties. It also provides the use of such compounds for the treatment and/or prophylaxis of conditions and diseases linked to abnormalities in glutamatergic transmission. It further provides a pharmaceutical composition for the treatment and/or prophylaxis of acute and chronic neurodegenerative conditions and disorders.

  本发明提供了显示抗谷氨酸作用的新化合物。它还提供了利用这些化合物治疗和/或预防与谷氨酸传递异常相关的疾病和疾病的用途。此外，还提供了用于治疗和/或预防急性和慢性神经退行性疾病和疾病的药物组合物。
• [EN] NEW COMPOUNDS WITH ANTIGLUTAMATERGIC PROPERTIES AND USES THEREOF<br/>[FR] NOUVEAUX COMPOSÉS À PROPRIÉTÉS ANTIGLUTAMATERGIQUES ET UTILISATIONS
  申请人：FAUST PHARMACEUTICALS

  公开号：WO2008098751A1

  公开（公告）日：2008-08-21

  [EN] The present invention provides new compounds displaying antiglutamatergic properties. It also provides the use of such compounds for the treatment and/or prophylaxis of conditions and diseases linked to abnormalities in glutamatergic transmission. It further provides a pharmaceutical composition for the treatment and/or prophylaxis of acute and chronic neurodegenerative conditions and disorders.
  [FR] nouveaux composés à propriétés antiglutamatergiques, utilisation de ces composés pour le traitement et/ou la prévention d'affections et de maladies liées à des anomalies de la transmission glutamatergique. Composition pharmaceutique pour le traitement et/ou la prévention d'affections et de troubles neurodégénératifs aigus et chroniques