2-Bromo-1,3-dimethoxy-5-(2-phenylethenyl)benzene | 678986-74-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-Bromo-1,3-dimethoxy-5-(2-phenylethenyl)benzene
• CAS: 678986-74-8
• 化学式: C₁₆H₁₅BrO₂
• 分子量: 319.19
• InChiKey: FSAQXUUAFIIOCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-Bromo-1,3-dimethoxy-5-(2-phenylethenyl)benzene 、 溴代十四烷 生成 1-(3,5-Dimethoxy-4-n-tetradecanylphenyl)-2-phenylethene
  参考文献：
  名称：

  Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues

  摘要：

  本发明提供了新型二苯乙烯化合物及其药学上可接受的盐。还提供了制造本发明化合物的方法，以及在治疗免疫、炎症和自身免疫性疾病中使用它们的方法。

  公开号：

  US20050059733A1

文献信息

• Anti-Inflammatory and Psoriasis Treatment and Protein Kinase Inhibition by Hydroxy Stilbenes and Novel Stilbene Derivatives and Analogues
  申请人：Chen Genhui

  公开号：US20080139666A1

  公开（公告）日：2008-06-12

  The present invention provides novel methods of treating psoriasis, protein tyrosine kinase-associated disorders, inflammation, epidermal hyperproliferation, diabetes, immune and autoimmune diseases, eczema, and inflammatory bowel disease, inhibiting protein kinase, neutrophil activation, cell proliferation, tumour growth, metastasis, and the development of atheromatous plaque and restonosis, controlling angiogenesis, and preventing inflammatory bowel disease, using hydroxystilbenes and novel stilbene derivatives.

  本发明提供了使用羟基苯乙烯和新型苯乙烯衍生物的治疗方法，包括治疗银屑病、蛋白酪氨酸激酶相关疾病、炎症、表皮细胞过度增殖、糖尿病、免疫和自身免疫疾病、湿疹、炎性肠病，抑制蛋白激酶、中性粒细胞激活、细胞增殖、肿瘤生长、转移和动脉粥样硬化斑块和再狭窄的发展，控制血管生成，预防炎症性肠病。
• ANTI-INFLAMMATORY AND PSORIASIS TREATMENT AND PROTEIN KINASE INHIBITION BY HYDROXY STILBENES AND NOVEL STILBENE DERIVATIVES AND ANALOGUES
  申请人：Chen Genhui

  公开号：US20100094041A1

  公开（公告）日：2010-04-15

  The present invention provides pharmaceutical compositions containing hydroxystilbenes or their derivatives or analogues. The pharmaceutical compositions are useful for protein kinase inhibition, and for treatment of psoriasis, eczema and inflammation.

  本发明提供含有羟基芪类或其衍生物或类似物的制药组合物。该制药组合物可用于蛋白激酶抑制和治疗牛皮癣、湿疹和炎症。
• Anti-inflammatory and psoriasis treatment and protein kinase inhibition by hydroxy stilbenes and novel stilbene derivatives and analogues
  申请人：Chen Genhui

  公开号：US20050059733A1

  公开（公告）日：2005-03-17

  The present invention provides novel diphenyl ethene compounds and pharmaceutically-acceptable salts thereof. Also provided are methods for making the compounds of the invention as well as methods for the use thereof in the treatment of immune, inflammatory, and auto-immune diseases.

  本发明提供了新型二苯乙烯化合物及其药学上可接受的盐。还提供了制造本发明化合物的方法，以及在治疗免疫、炎症和自身免疫性疾病中使用它们的方法。