| 71002-10-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• CAS: 71002-10-3
• 化学式: C10H14N5NaO7P
• 分子量: 370.21
• InChiKey: JWJUYEHEBGNNAE-CAMOTBBTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.24
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  186
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• METHODS FOR FINE PARTICLE MANUFACTURE
  申请人：Board of Regents, The University of Texas System

  公开号：US20150050345A1

  公开（公告）日：2015-02-19

  Processes for preparing micronized particles comprising a poorly water soluble bioactive agent are provided. The processes utilize a superheated aqueous phase which can serve as the continuous phase of an emulsion. The superheated aqueous phase can be used to melt poorly water soluble bioactive agents and/or matrix materials which them form molten droplets dispersed within the superheated aqueous phase. The size and size distribution of the molten droplets can be controlled using a variety of suitable methods. The molten droplets can then be cooled to form micronized particles comprising the poorly water soluble bioactive agent. If desired, the cooling rate can be selected to control the crystalline morphology of the resulting micronized particles.

  提供了制备含有难溶性生物活性剂的微粒子的过程。该过程利用超热水相，可以作为乳液的连续相。超热水相可以用于熔化难溶性生物活性剂和/或基质材料，形成分散在超热水相中的熔融液滴。可以使用各种适当的方法来控制熔融液滴的大小和大小分布。然后，可以将熔融液滴冷却以形成含有难溶性生物活性剂的微粒子。如果需要，可以选择冷却速率来控制所得微粒子的晶体形态。
• Method for preparing a solid dispersion, solid dispersion obtained thereby and use thereof
  申请人：King Saud University

  公开号：EP2649989A1

  公开（公告）日：2013-10-16

  The present invention relates to a method for preparing a solid dispersion, comprising the steps: a.1) melting of a mixture of at least one drug, at least one carrier and at least one acid, at least one carbonate and/or at least one bicarbonate and optinally at least one surfactant under effervescence of CO2; or a.2) melting of at least one of the constituents of the mixture according to step a.1) and adding the remaining constituents in arbitrary order under effervescence of CO2 wherein either the at least one acid or the at least one bicarbonate and/or the at least one carbonate has/ have to be added last; b) solidifying the mixture obtained in step a.1 or a.2), preferably by cooling and optionally drying; c) comminuting the mixture obtained in step b). a solid dispersion prepared thereby, a pharmaceutical composition containing the solid dispersion as well as the use of the solid dispersion for enhancing the water solubility of drugs.

  本发明涉及一种制备固体分散体的方法，包括以下步骤 a.1) 将至少一种药物、至少一种载体和至少一种酸、至少一种碳酸盐和/或至少一种碳酸氢盐以及可选的至少一种表面活性剂的混合物在二氧化碳的气泡作用下熔化； 或 a.2) 熔化步骤 a.1) 所述混合物中的至少一种成分，然后在二氧化碳气泡作用下按任意顺序加入其余成分，其中至少一种酸或至少一种碳酸氢盐和/或至少一种碳酸盐必须最后加入； b) 将在步骤 a.1 或 a.2) 中得到的混合物固化，最好是通过冷却，也可选择干燥； c) 粉碎在步骤 b) 中得到的混合物。 由此制备的固体分散体、含有该固体分散体的药物组合物以及该固体分散体在提高药物水溶性方面的用途。
• Inhalable pharmaceutical compositions
  申请人：Bosch H. William

  公开号：US10022303B2

  公开（公告）日：2018-07-17

  Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.

  描述了制造包含药用活性剂的可吸入复合颗粒的方法，该方法包括：a) 提供包含可研磨基质和固体药用活性剂的复合颗粒，其中药用活性剂的体积平均中值粒径在 50 nm 至 3 μm 之间；以及 b) 在不含研磨体的研磨机中研磨复合颗粒，研磨时间足以产生可吸入复合颗粒，该复合颗粒的质量中值空气动力学直径在 1 μm 至 20 μm 之间。
• Drug device configured for wireless communication
  申请人：POP TEST ABUSE DETERRENT TECHNOLOGY LLC

  公开号：US10010703B2

  公开（公告）日：2018-07-03

  This invention relates to an ingestible drug delivery device configured for wireless communication with other ingestible drug delivery devices.

  本发明涉及一种可与其他可食用给药装置进行无线通信的可食用给药装置。
• Fast dissolving solid dosage form
  申请人：Lim Chin Beng Stephen

  公开号：US10744086B2

  公开（公告）日：2020-08-18

  There is provided a fast dissolving solid dosage form adapted for the release of a biologically active material in the oral cavity wherein the dosage form comprises at least one biologically active material, and at least one matrix forming agent, wherein the dosage form substantially dissolves in the oral cavity. A method of producing the same and a kit comprising the same are also provided.

  提供了一种可在口腔中释放生物活性物质的速溶固体制剂，其中制剂包括至少一种生物活性物质和至少一种基质形成剂，制剂在口腔中基本溶解。此外，还提供了生产该制剂的方法和包含该制剂的试剂盒。