Diethyl (4-nitro-1-naphthyl)methylphosPhonate | 175394-12-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: Diethyl (4-nitro-1-naphthyl)methylphosPhonate
• 英文别名: 1-(Diethoxyphosphorylmethyl)-4-nitronaphthalene
• CAS: 175394-12-4
• 化学式: C₁₅H₁₈NO₅P
• 分子量: 323.285
• InChiKey: IULPHDZKVFFKMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NITRODIARYLETHENES AS FLUORESCENCE QUENCHERS FOR NUCLEIC ACID PROBES
  申请人：ELITechGroup MDX, LLC

  公开号：US20220119424A1

  公开（公告）日：2022-04-21

  Fluorescence quenching nitrodiarylethene analogs are useful in oligonucleotide conjugates and probes. These analogs, whose absorption spectra are substantially blue-shifted relatively to emission spectra of common fluorophores (such as fluorescein), do not need to rely on spectral overlap of quencher absorbance and fluorophore's emission for their quenching abilities. The oligonucleotide-quencher conjugates may be used in detection methods for nucleic acid targets.