| 1172131-27-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1172131-27-9
• 化学式: C₂₂H₂₁N₃O₂S
• 分子量: 391.494
• InChiKey: RZERGMUUCWXHFP-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 甲醇 、 potassium hydroxide 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Identification of a novel series of 3-piperidinyl-5-sulfonylindazoles as potent 5-HT6 ligands

  摘要：

  Cognitive dysfunction is a characteristic of various forms of dementia such as Alzheimer's disease (AD) and a core feature of schizophrenia. As part of our continuing efforts to develop agents for cognitive enhancement, we have been focused on the 5-HT6 receptor-one of the emerging therapeutic targets in this area. Herein, we report the identification of a novel series of 3-piperidinyl-5-sulfonylindazole derivatives as potent 5-HT6 antagonists. The synthesis and SAR of this class of compounds are reported. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.04.108