3-(2-bromo-4,5-difluorophenyl)propanoic acid | 881189-69-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-(2-bromo-4,5-difluorophenyl)propanoic acid
• CAS: 881189-69-1
• 化学式: C₉H₇BrF₂O₂
• 分子量: 265.054
• InChiKey: NTSRYKALKGEJAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS<br/>[FR] NOUVEAUX DÉRIVÉS D'ACIDE INDANYLOXYDIHYDROBENZOFURANNYLACÉTIQUE ET LEUR UTILISATION COMME AGONISTES DU RÉCEPTEUR GPR40
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2013144098A1

  公开（公告）日：2013-10-03

  The present invention relates to compounds of general formula (I), wherein the groups R1, R2 and m are defined as in claim 1, which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  本发明涉及一般式(I)的化合物，其中基团R1、R2和m的定义如权利要求书中所述，这些化合物具有有价值的药理特性，特别是与GPR40受体结合并调节其活性。这些化合物适用于治疗和预防受该受体影响的疾病，如代谢性疾病，特别是2型糖尿病。
• Cyclic amine derivative or salt thereof
  申请人：Hayashibe Satoshi

  公开号：US20070197594A1

  公开（公告）日：2007-08-23

  Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its salt characterized in that the amine-containing structure A therein bonds to a 2- or 3-cyclic condensed ring (e.g., indane, tetralone, 4,5,6,7-tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H-indeno[4,5-b]furan, 2,3-dihydro- 1 H-cyclopenta[1]naphthalene) via X 1 (bond or lower alkylene); and an NMDA antagonist containing it as an active ingredient thereof.

  提供的化合物是NMDA受体拮抗剂，具有广泛的安全边界，并可用作治疗或预防阿尔茨海默病、脑血管性痴呆、帕金森病、缺血性卒中、疼痛等药物。具体提供的是胺衍生物或其盐，其特点在于其中含有胺基结构A，通过X1（键或低碳烷基）与2-或3-环状紧缩环（例如茚烷、四氢萘酮、4,5,6,7-四氢苯并噻吩、4,5,6,7-四氢苯并呋喃、7,8-二氢-6H-茚并[4,5-b]呋喃、2,3-二氢-1H-环戊[1]萘烷）结合；以及含有它作为有效成分的NMDA受体拮抗剂。
• NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACID DERIVATIVES AND THEIR USE AS GPR40 RECEPTOR AGONISTS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2831053A1

  公开（公告）日：2015-02-04
• LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY INCLUDING THE SAME
  申请人：Samsung Display Co., Ltd.

  公开号：US20160257881A1

  公开（公告）日：2016-09-08

  A liquid crystal composition includes at least one polar liquid crystal compound represented by Chemical Formula PI-1 to PI-4: in which each n, n1, and n2 in Chemical Formula PI-1 to PI-4 is any one of 1, 2, and 3, in Chemical Formula PI-1 to PI-4, each A, A1, and A2 includes one of each L1 to L8 includes one of —H, —F, —Cl, —OCF 3 , —CF 3 , —CH 2 F, and —CHF 2 , each Z, Z1, and Z2 includes one of single bond, —COO—, —OCO—, —CF 2 O—, —OCF 2 —, —CH 2 O—, —OCH 2 —, —SCH 2 —, —CH 2 S—, —CH 2 CH 2 —, —C 2 F 4 —, —CH 2 —CF 2 —, —CF 2 CH 2 —, —(CH 2 ) Z — (z is 1 to 3), —CH═CH—, —CF═CF—, —CH═CF—, —CF═CH—, —C═C—, and —CH═CHCH 2 O—, and R includes one of hydrogen, halogen, a cyano group, alkyl group, and an alkoxy group including 1 to 12 carbon atoms.
• US9683172B2
  申请人：——

  公开号：US9683172B2

  公开（公告）日：2017-06-20