(1,4-diaza-bicyclo[3.2.2]non-4-yl)-5-nitro-furan-2-yl-methanone hydrochloric acid salt | 753499-10-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 呋喃
• 英文名称: (1,4-diaza-bicyclo[3.2.2]non-4-yl)-5-nitro-furan-2-yl-methanone hydrochloric acid salt
• 英文别名: 1,4-Diazabicyclo[3.2.2]nonan-4-yl-(5-nitrofuran-2-yl)methanone;hydrochloride
• CAS: 753499-10-4
• 化学式: C₁₂H₁₅N₃O₄*ClH
• 分子量: 301.73
• InChiKey: ZLSWUDTXVJOICZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.53
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  82.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel diazabicyclic aryl derivatives
  申请人：Peters Dan

  公开号：US20060148789A1

  公开（公告）日：2006-07-06

  This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型二氮杂双环芳基衍生物，发现它们是乙酰胆碱受体上的胆碱能配体。由于它们的药理特性，本发明中的化合物可能有用于治疗多种与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或障碍，与平滑肌收缩有关的疾病或障碍，内分泌疾病或障碍，与神经退行性有关的疾病或障碍，与炎症、疼痛以及化学物质滥用终止引起的戒断症状相关的疾病或障碍。
• NOVEL DIAZABICYCLIC ARYL DERIVATIVES
  申请人：PETERS Dan

  公开号：US20100130483A1

  公开（公告）日：2010-05-27

  This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型二氮杂双环芳基衍生物，其被发现是尼古丁乙酰胆碱受体的胆碱能配体。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩相关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症相关的疾病或障碍、疼痛和化学物质滥用终止引起的戒断症状等多种疾病或障碍具有用处。
• US7678788B2
  申请人：——

  公开号：US7678788B2

  公开（公告）日：2010-03-16