2-amino-3-indol-3-yl-3-phenyl-propionic acid | 51626-63-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 2-amino-3-indol-3-yl-3-phenyl-propionic acid
• 英文别名: 2-Amino-3-(indol-3-yl)-3-phenylpropionic acid；2-amino-3-(1H-indol-3-yl)-3-phenylpropanoic acid
• CAS: 51626-63-2
• 化学式: C₁₇H₁₆N₂O₂
• 分子量: 280.326
• InChiKey: HOFODQDKUBDHCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  79.1
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• PROCESS FOR PURIFICATION OF IMMUNOGLOBULINS USING A PSEUDOBIOAFFINITY ADSORBENT
  申请人：Lali Arvind Mallinath

  公开号：US20100113746A1

  公开（公告）日：2010-05-06

  The present invention relates to the development of pseudobioaffinity adsorbent and process for purification of immunoglobulin G from immunoglobulin containing solutions such as but not limited to plasma, serum, cell culture supernatant, ascites fluids. The adsorbent consists of a solid support and ligand. The ligand may be attached to the matrix or be part of matrix. The ligand is selected from a group of hydrophobic amino acids such as alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan and tyrosine and the support material being preferably a synthetic hydrophilic polymer of methacrylate or acrylate species, or any of its derivatives. The adsorbent is cheap and stable to harsh conditions such as 1.0 M NaOH used during regeneration of adsorbents. Moreover there is no problem of toxic leachables typically associated with biological ligands. The nature of the adsorbent also allows high flow rate operations at relatively low pressures. The process includes adjusting the pH and conductivity of the feed solution and the use of ionic salts and additives such as polyols or alcohols for eluting the bound IgG.
• [EN] A PROCESS FOR PURIFICATION OF IMMUNOGLOBULINS USING A PSEUDOBIOAFFINITY ADSORBENT<br/>[FR] PROCÉDÉ DE PURIFICATION D'IMMUNOGLOBULINES AU MOYEN D'UN ADSORBANT FONCTIONNANT PAR PSEUDOBIOAFFINITÉ
  申请人：LALI ARVIND MALLINATH

  公开号：WO2009007993A2

  公开（公告）日：2009-01-15

  The present invention relates to the development of pseudobioaffinity adsorbent and process for purification of immunoglobulin G from immunoglobulin containing solutions such as but not limited to plasma, serum, cell culture supernatant, ascites fluids. The adsorbent consists of a solid support and ligand. The ligand may be attached to the matrix or be part of matrix. The ligand is selected from a group of hydrophobic amino acids such as alanine, valine, leucine, isoleucine, proline, phenylalanine, tryptophan and tyrosine and the support material being preferably a synthetic hydrophilic polymer of methacrylate or acrylate species, or any of its derivatives. The adsorbent is cheap and stable to harsh conditions such as 1.0 M NaOH used during regeneration of adsorbents. Moreover there is no problem of toxic leachables typically associated with biological ligands. The nature of the adsorbent also allows high flow rate operations at relatively low pressures. The process includes adjusting the pH and conductivity of the feed solution and the use of ionic salts and additives such as polyols or alcohols for eluting the bound IgG.