(S)-4-(4-fluoro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid [1-(2-hydroxy-ethyl)-3,5-dimethyl-1H-indol-6-yl]-amide | 1232684-80-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: (S)-4-(4-fluoro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid [1-(2-hydroxy-ethyl)-3,5-dimethyl-1H-indol-6-yl]-amide
• 英文别名: (4S)-4-(4-fluorophenyl)-N-[1-(2-hydroxyethyl)-3,5-dimethylindol-6-yl]-2-oxo-3,4-dihydro-1H-pyridine-5-carboxamide
• CAS: 1232684-80-8
• 化学式: C₂₄H₂₄FN₃O₃
• 分子量: 421.471
• InChiKey: GDEOHCWMZOPCJM-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  83.4
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS
  申请人：Berger Jacob

  公开号：US20100160373A1

  公开（公告）日：2010-06-24

  Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R 1 , R 2 , R 3 , R 4 , R 5 and R a are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

  公式I的化合物：或其药用盐，其中m，n，R1，R2，R3，R4，R5和Ra如本文所定义。还公开了制备这些化合物的方法以及利用这些化合物治疗与P2X7嘌呤受体相关的疾病的方法。
• US8372865B2
  申请人：——

  公开号：US8372865B2

  公开（公告）日：2013-02-12
• [EN] DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS<br/>[FR] DIHYDROPYRIDONE AMIDES EN TANT QUE MODULATEURS DE P2X7
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010072597A1

  公开（公告）日：2010-07-01

  Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.