2-(10-amino-decylamino)-naphthacene-[1,4]-dione trifluoroacetate | 1055230-16-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 并四苯
• 英文名称: 2-(10-amino-decylamino)-naphthacene-[1,4]-dione trifluoroacetate
• CAS: 1055230-16-4
• 化学式: C₂HF₃O₂*C₂₈H₃₂N₂O₂
• 分子量: 542.598
• InChiKey: OINAMPCGKTUIDO-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  、 三氟乙酸 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 2-(10-amino-decylamino)-naphthacene-[1,4]-dione trifluoroacetate
  参考文献：
  名称：

  Parallel Synthesis and Cytotoxicity Evaluation of a Polyamine−Quinone Conjugates Library

  摘要：

  A library of 24 derivatives designed by combining two natural products-derived fragments was prepared and tested to determine their anticancer potential in HT29 colon cancer cells. All library members inhibit cell proliferation as measured by MTT mitochondrial functional assay, with IC50 values in the 1-100 mu M range. Entry 1b caused apoptotic EGFR-mediated intracellular signaling. Thus, polyamino-quinones emerged as readily accessible and easily diversified scaffolds for anticancer lead discovery.

  DOI：

  10.1021/jm800637b